High Throughput Screening: The Discovery of Bioactive Substances

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high

Table of Contents:
Natural Products as a Discovery Resource, edited by John P. Devlin Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin Microcollection of Plants for Biochemical Profiling, John P. Devlin Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman The Marine Environment as a Discovery Resource, Gregg R. Dietzman Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia Introduction, Michael R. Pavia Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dorner, John M. Ostresh, Colette Dooley, and Richard A. Houghten Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson Parallel Organic Synthesis Using Parke-Davis' Diversomer Method, Sheila Hobbs DeWitt and Anthony W. Czarnik Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and Laszlo Kovacs Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder Assay Technologies and Detection Methods, edited by Alfred J. Kolb Introduction, Alfred J. Koin Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes FlashPlate Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompk

Review :
" …a valuable reference. "-Journal of Pharmacy and Pharmacology "…a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances…. …a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries. "-Journal of Medicinal Chemistry "…an excellent compendium…covering the breath of current HTS. It will serve as a standard text in the field. "-Journal of Natural Products This recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design. - European Journal of Pharmaceutics and Biopharmaceutics, 2000