Platelet-Activating Factor and Related Lipid Mediators
Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Platelet-Activating Factor and Related Lipid Mediators
Platelet-Activating Factor and Related Lipid Mediators

Platelet-Activating Factor and Related Lipid Mediators


     0     
5
4
3
2
1



International Edition


X
About the Book

Platelet-activating factor (PAF) is the commonly used name for a group of potent biologically active, ether-linked phospholipids, the alkylacetylglycerophospho­ cholines. Following the identification of the chemical structure of P AF in 1979, much progress has been made in our understanding of these phospholipid medi­ ators. This is particularly true from the points of view of their molecular structural requirements for expression of biological activity, their biosynthesis and cata­ bolism, their diverse range of biological activities, evidence for their specific recep­ tors at the cell surface, the development of specific antagonists for use in receptor studies and for testing as potential anti-PAF drugs, and implications about their involvement in health and disease. Chapters in this book cover the current status of these general areas of PAF research. Although an enormous amount of information has been published about this interesting new type of phospholipid mediators, questions about their mechanism of action, regulatory controls, and the precise role and relative importance of P AF in specific diseases and physiological functions remain to be answered. Since the 1979 discovery, the PAF field has brought together scientists from a variety of different biomedical disciplines. The diversity of scientists now in PAF research is very apparent from the number of P AF publications appearing in a wide array of scientific journals, ranging from molecular biology to clinical medicine. Publications related to PAF continue to increase at an amazingly rapid rate, with the pace reminiscent of the period following the discovery of prostaglandins.

Table of Contents:
Introduction: Historical Aspects of Alkyl Lipids and Their BiologicallyActive Forms (Ether Lipids,Platelet-Activating Factor, andAntihypertensive Renal Lipids).- I. Methodology and Chemistry.- 1. Chemical Synthesis and Mass Spectrometry of PAF.- 2. Chromatographic Analyses of Ether-Linked LipidsInvolved in PAF Metabolism.- II. Composition.- 3. Composition of Alkyl Ether-Linked Phospholipids in Mammalian Tissues.- III. Enzymes.- 4. Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, their Precursors.- 5. Enzymatic Control of the Cellular Levels of Platelet-Activating Factor.- IV. Antagonists, Agonists, and Receptors.- 6. Platelet-Activating Factor Binding to Specific Cell Membrane Receptors.- 7. The Chemical and Biological Properties of PAF Agonists, Antagonists and Biosynthetic Inhibitors.- 8. Conformational Properties of the PAF-Acether Receptor on Platelets Based on Structure—Activity Studies.- V. Biochemical and Biological Aspects in Specific Cells and Tissues.- 9. Diversity of the Biochemical and Biological Behavior of Platelet-Activating Factor.- 10. Extracellular and Intracellular Activities of PAF.- 11. Interrelationships in the Metabolism of Platelet-Activating Factorand Arachidonate in Neutrophils.- 12. Platelet-Activating Factor: Mechanisms of Cellular Activation.- 13. The Role of Platelet-Activating Factor in Inflammation.- 14. The Production of Platelet-Activating Factor by Cultured Human Endothelial Cells: Regulation and Function.- 15. Bronchopulmonary Pharmacology of PAF-Acether.- 16. Platelet-Activating Factor: A Secretory Product from Phagocytes.- 17. Functions of PAF in Reproduction and Development: Involvement of PAF in Fetal Lung Maturation and Parturition.- 18. Effect of PAF on the Cardiovascular System.- 19.Biosynthesis and Release of PAF-Acether by Mouse Bone Marrow-Derived Mast Cells.- VI. Antitumor Analogs of PAF.- 20. Antineoplastic Actions of Ether Lipids Related to Platelet-Activating Factor.


Best Sellers


Product Details
  • ISBN-13: 9781468452860
  • Publisher: Springer-Verlag New York Inc.
  • Publisher Imprint: Springer-Verlag New York Inc.
  • Height: 229 mm
  • No of Pages: 492
  • Returnable: N
  • ISBN-10: 146845286X
  • Publisher Date: 22 Mar 2012
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Width: 152 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Platelet-Activating Factor and Related Lipid Mediators
Springer-Verlag New York Inc. -
Platelet-Activating Factor and Related Lipid Mediators
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Platelet-Activating Factor and Related Lipid Mediators

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!