Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin: (265 NATO Science Series A:)

This book is based upon a series of papers originally presented at a NATO Advanced Studies Workshop of the same title held at the study Center HI Cappuccini," a converted monastery in San Miniato, a small village located between Pisa and Florence, Italy, in October 1991. Authors were asked to submit their completed chapters by the following February; these were then scanned onto computer disks, edited and returned to the authors for final revision, and updating, with a final deadline of February 1993. The authors were encouraged to make whatever modifications they wanted, especially regarding updating their chapters, with an eye to making the final product both comprehensive and current. In this we succeeded beyond our expectations, with most chapters extensively altered and many completely re-written and significantly expanded. Thus, although the original meeting was held in 1991, the chapters in this volume may be regarded as current from at least February, 1993, with some of the final updated revisions received as late as July, 1993. This book, as agreed in our original contract, has been delivered to the publisher "camera-ready. " This means that all of the scanning, editing, proofing and typesetting were done here, by the office of the Department of Dermatology at the New Jersey Medical School. We essentially produced the book, which the publisher, for the most part, then photocopied. This has been an enormous burden, borne mainly by my colleague in this division, Robert A.

Table of Contents:
?-? T lymphocytes in mice and man: A review.- Ontogeny, features and functions of epidermal T lymphocytes.- Activation of reactive versus malignant T-cells in cutaneous T-cell lymphoma: Role of abnormal antigen presenting cells and T-cell activating molecules.- Factors involved in the localization and activation of murine ?-? positive dendritic epidermal T cells.- Morpho-antigenic features of dendritic cells as a clue to the interpretation of skin immune system-related disorders.- Cell trafficking networks in cutaneous T-cell lymphoma.- Cytokine neuropeptide interactions in the skin.- Effect of UV light on cytokine production by epidermal cells.- Adhesion molecules involved in the extravasation of lymphocytes in lymphoid organs and chronically inflamed tissues.- Adhesion receptors in normal skin and cutaneous malignant lymphomas: Pathophysiological and clinical correlations.- Integrins and homing receptors in cutaneous lymphomas.- A new retrovirus from cutaneous T-cell lymphoma.- Survey of cutaneous T-cell lymphomas for human T-lymphotropic virus infection.- HTLV-I proviral sequences in cutaneous CD30+ T-large cell lymphomas.- Presence of Epstein-Barr viral DNA and EBV latent gene products in Hodgkin and non-Hodgkin lymphoma: High expression of EBV-DNA sequences in non-Hodgkin lymphoma with variable numbers of CD30 positive cells.- Inflammatory precursors of mycosis fungoides.- The histological spectrum of cutaneous T-cell lymphoma.- Cutaneous T-cell lymphoma: Clues to diagnosis in early lesions.- Morphologic and prognostic features of advanced mycosis fungoides.- Primary cutaneous CD30 (Ki-1) positive large cell lymphomas: Definition and differential diagnostic aspects.- Analysis of clinical, histopathologic and immunopathologic parameters in erythrodermic variantsof cutaneous T-cell lymphoma with implications for staging.- A scoring system based on differentially weighted criteria for establishing a standardized threshold for the diagnosis of early mycosis fungoides.- Cutaneous B-cell lymphoma: A SALT-related tumor?.- Proliferation activity in skin lesion of mycosis fungoides: Prognostic and pathophysiologic implications.- Erythrodermc actinic reticuloid.- Morphometric study of primary cutaneous germinal center cell lymphomas.- BCL-2 gene rearrangement and protein expression in primary cutaneous B-cell lymphomas.- Changing concepts on cutaneous pseudo-B-cell lymphomas and their relationship to cutaneous B-cell lymphomas.- Diagnostic and prognostic significance of clonal T-cell receptor gene rearrangements in the peripheral blood of patients with cutaneous T-cell lymphoma.- Analysis of T-cell receptor gene configurations in mycosis fungoides.- The pathogenesis of lymphomatoid papulosis.- T-cell receptor variable region gene expression in cutaneous T-cell lymphoma.- Sézary syndrome is characterized by genotraumatic T-cells.- Chromosome abnormalities in cutaneous B-cell lymphomas.- Mechanism for tumor progression in lymphomatoid papulosis: Hypothesis based on studies of tumor cell lines clonally derived from lymphomatoid papulosis.- Shedding of interleukin-2 receptor in cutaneous lymphomas: An effective mechanism to circumvent immunosurveillance?.- The skin as a target organ during IL-2 administration.- Specific immune response against melanoma: Analysis at a clonal level.- Response of early stage cutaneous T-cell lymphoma to ultraviolet B phototherapy.- A murine T-cell lymphoma model showing protection against tumor development and treatment of established disease.- Molecular mechanisms responsible for repair of adducts inducedin human cellular DNA by PUVA.- Interferon modulates lymphoproliferation in the skin.- Use of recombinant interferon-?-2a in the treatment of cutaneous lymphomas of T- and B-cell lineage.- Thymopentin in Sézary syndrome: Clinical and immunological effects.- What is mycosis fungoides? A modest proposal.- Terms and abbreviations used used in cutaneous lymphoproliferative phenomena.- Conference picture.- Index of authors and conference participants.