Platelet-Vessel Wall Interactions
Home > Medicine & Health Science textbooks > Clinical and internal medicine > Haematology > Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)
Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)

Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)


     0     
5
4
3
2
1



International Edition


X
About the Book

The publication of Platelet-Vessel Wall Interactions, the second monograph in the Bloomsbury Series in Clinical Science, is particu­ larly welcome as its appearance signifies the further development of the Series and its potential for the future. The theme of this monograph is the pathophysiology of atherosclerosis, a topic that symbolises the aim of the Series, namely to highlight the important interfaces between basic medical science and clinical practice. Our congratulations to the Editors and contributors. London, December 1987 lack Tinker Preface In the Western world, atherosclerosis causes more illness and death than any other disease. Despite its devastating effects, the pathogenesis of the disease remains a matter for hypothesis and con­ jecture. This monograph owes its conception to a programme of work directed towards understanding the basic pathophysiology of atherosclerosis. The circulatory system is lined by vascular endothelium which has a central role in maintaining the integrity of the vessel wall and prevent­ ing thrombosis. The natural equilibrium existing between normal en­ dothelium which supports blood flow, and platelets which serve to re­ pair damaged endothelium, is explored in the first two chapters. Atherosclerosis developing as a response to endothelial injury is one hypothesis which has stimulated widespread interest, and re­ search has largely been directed towards finding the injurious agent.

Table of Contents:
1 The Platelet.- Morphology.- Platelet Function.- Biochemistry.- Platelet Coagulant Activity.- 2 Endothelium and the Vessel Wall.- General Introduction.- General Structure of the Vessel Wall.- Vascular Endothelium.- Endothelial Permeability.- Synthetic and Metabolic Functions.- Endothelial Regeneration.- Endothelial Injury.- 3 The Use of Cultured Endothelial Cells in the Study of Platelet-Vessel Wall Interactions.- The Culturing of Vascular Endothelial Cells.- Growth Factors.- Extracellular Matrix Proteins.- Arachidonic Acid Metabolism.- In Vitro Assessment of Platelet Interaction with the VesselWall.- Assessment of Cytotoxicity using Cultured Endothelial Cells.- The Effect of Nicotine on Endothelial Cells.- Conclusion.- 4 Smoking and Platelet-Vessel Wall Interactions.- The Effects of Cigarette Smoke, Carbon Monoxide and Nicotine on Endothelial Morphology and Platelet-Endothelial Cell Interactions.- Cigarette Smoking and Platelet Aggregation.- Cigarette Smoking and Endothelial Cell Prostacyclin Production.- Novel Methods for Studying the Effects of Cigarette Smoking on Endothelium and Platelets.- Conclusions.- 5 Mesothelium as a Non-thrombogenic Surface.- Embryology.- Morphology.- Function.- Mesothelium as an Endothelium Substitute.- 6 Platelet-Endothelial Interactions in Renal Injury.- I. Potential Role for Platelets in Mediating Renal Injury.- to Renal Injury.- Evidence for Platelet Involvement in Glomerular Injury in Man.- How Platelets may Contribute to Renal Injury.- Mechanisms of Platelet Activation.- Role of Platelets in Experimental Models of Renal Injury.- II. Disorders of Platelet Function in Different Renal Diseases.- Nephrotic Syndrome.- Acute Renal Failure.- Pre-eclampsia.- Uraemia.- Dialysis.- 7 Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review.- Aetiology.- Pathology.- Pathogenesis.- Haemostatic Changes in Haemolytic Uraemic Syndrome.- Treatment.- 8 Newer Pharmacological Agents.- Inhibition of Arachidonic Acid Pathway/Reduction of Synthesis of Thromboxane A2.- Thromboxane Receptor Blockade.- Inhibition of Calcium Fluxes.- Elevation of Intra-Platelet Cyclic AMP Levels.- Protection of Endogenous Prostacyclin Release.- Promotion of Endogenous Prostacyclin Release.- Supplementation of Endogenous Prostacyclin.- Other Agents.


Best Sellers


Product Details
  • ISBN-13: 9781447114574
  • Publisher: Springer London Ltd
  • Publisher Imprint: Springer London Ltd
  • Height: 244 mm
  • No of Pages: 198
  • Returnable: N
  • Width: 170 mm
  • ISBN-10: 1447114574
  • Publisher Date: 15 Nov 2011
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Series Title: The Bloomsbury Series in Clinical Science


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)
Springer London Ltd -
Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Platelet-Vessel Wall Interactions: (The Bloomsbury Series in Clinical Science)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!