Cystic Fibrosis, Third Edition

This international and authoritative work, which brings together current knowledge in the field of cystic fibrosis, has become established in previous editions as a leading reference in the field. The third edition continues to provide everything that the clinician or allied health professional treating patients with cystic fibrosis will need in a single manageable volume. Thoroughly revised and updated throughout, it reflects the significant advances that have been made in the field since the second edition published in 2000. Cystic Fibrosis evaluates in detail the basic science that underlies the disease and its progression, putting it into a clinical context. Diagnostic and clinical aspects are covered in depth, as are monitoring the condition and the importance of multi-disciplinary care, reflected in the sections into which the new edition has been sub-divided to improve accessibility. Future developments, including novel therapies, are covered in a concluding section. The clinical areas have been much expanded, with the introduction of separate chapters covering sleep, lung mechanics and the work of breathing, upper airway disease, insulin deficiency and diabetes, bone disease, and sexual and reproductive issues. A new section on monitoring discusses the use of databases to improve patient care, and covers monitoring in different age groups, exercise testing and the outcomes of clinical trials in these areas. Separate chapters are devoted to paramedical issues, including nursing, physiotherapy, psychology, and palliative and spiritual care. Throughout, the emphasis is on providing an up-to-date and balanced review of both the clinical and basic sciences aspects of the subject, and to reflect the multi-disciplinary nature of the cystic fibrosis care team. Drawing on the expertise of a team of international specialists from a variety of backgrounds, the third edition of Cystic Fibrosiswill continue to find a broad readership among respiratory physicians, paediatricians, specialist nurses and other health professionals working with patients with cystic fibrosis.

Table of Contents:
PART 1 INTRODUCTION: WHAT IS CYSTIC FIBROSIS? 1 History of cystic fibrosis 2 Epidemiology of cystic fibrosis PART 2 BASIC SCIENCE FOR THE CLINICIAN 3 Molecular biology of cystic fibrosis: CFTR processing and functions, and classes of mutations 4 Pathophysiology: epithelial cell biology and ion channel function in the lung, sweat gland and pancreas 5 Immunology of cystic fibrosis 6a Genotype–phenotype correlations and modifier genes 6b Variability of clinical course in cystic fibrosis PART 3 DIAGNOSTIC ASPECTS OF CYSTIC FIBROSIS 7 Diagnosis of cystic fibrosis 8a The challenge of screening newborn infants for cystic fibrosis 8b How to manage the screened patient 9 Microbiology of cystic fibrosis PART 4 CLINICAL ASPECTS OF CYSTIC FIBROSIS 10 Respiratory disease: infection 11 Respiratory disease: non-infectious complications 12 Sleep, lung mechanics and work of breathing, including NIPPV 175 13 Delivery of therapy to the cystic fibrosis lung 14 The upper airway in cystic fibrosis 15a Gastrointestinal disease in cystic fibrosis 15b Liver, biliary and pancreatic disease 16 Insulin deficiency and diabetes related to cystic fibrosis 17 Growth and puberty 18 Cystic-fibrosis-related low bone mineral density 19 Other system disorders in cystic fibrosis 20 Sexual and reproductive health 21 Transplantation PART 5 MONITORING 22 Using databases to improve care 23a Infant and pre-school children: lung function 23b Infant and pre-school children: role of bronchoscopy 23c Infant and pre-school children: imaging the lungs 24 Physiological monitoring of older children and adults 2 5a Exercise: testing 25b Exercise: use in therapy 26 Clinical outcome measures to assess new treatments for cystic fibrosis lung disease PART 6 MULTIDISCIPLINARY CARE 27 Cystic fibrosis center care 28 Nursing care 29 Physiotherapy 30 Nutritional aspects 31 Psychological aspects of cystic fibrosis 433 Alistair J. A. Duff and Helen Oxley 32 Palliative care in cystic fibrosis PART 7 CYSTIC FIBROSIS: THE FUTURE 33a Gene and stem cell therapy 33b Non-gene therapy treatments: what will they deliver?

About the Author :
Margaret Hodson, Professor of Respiratory Medicine and Consultant Physician, Department of Cystic Fibrosis; Duncan Geddes, Professor of Respiratory Medicine and Consultant Physician; Andrew Bush, Professor of Paediatric Respirology; All at the Royal Brompton & Harefield NHS Trust, London, UK

Review :
"The book achieves its likely intended goals well. To an average practitioner, it comes across as very accessible. I consider it a practical resource that I would add to my personal library." Joel Seidman, Doody's Book Review Service "This book is the definitive CF text ... This book will be invaluable to any doctor or allied health professional involved in the treatment and care of CF patients." Dr Jeremy Sager, Univadis/Medix "the book is practical and provides the reader with up-to-date information on the disease. No other textbook of this magnitude is available in the field of cystic fibrosis." The New England Journal of Medicine, April 2008 "This volume provides a wide range, multidisciplinary updated review on cystic fibrosis. With many helpful illustrations. For all health professionals who care for children and adolescents with cystic fibrosis." Pediatric Endocrinology Reviews, December 2008