Testing Statistical Hypotheses of Equivalence and Noninferiority
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Testing Statistical Hypotheses of Equivalence and Noninferiority

Testing Statistical Hypotheses of Equivalence and Noninferiority


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About the Book

Giving much more attention to noninferiority testing, this second edition provides readers with a rich repertoire of efficient solutions to specific equivalence and noninferiority testing problems frequently encountered in the analysis of real data sets. It also includes new chapters on equivalence tests for multivariate data and tests for relevant differences between treatments. Drawing from real-life medical research, the author uses numerous examples throughout to illustrate the methods. Updated computer programs in SAS, Fortran, and R for facilitating the routine application of testing procedures are available online at www.crcpress.com

Table of Contents:
Introduction. General Techniques for Dealing with Noninferiority Problems. General Approaches to the Construction of Tests for Equivalence in the Strict Sense. Equivalence Tests for Selected One-Parameter Problems. Equivalence Tests for Designs with Paired Observations. Equivalence Tests for Two Unrelated Samples. Multisample Tests for Equivalence. Equivalence Tests for Multivariate Data. Tests for Establishing Goodness of Fit. The Assessment of Bioequivalence. Tests for Relevant Differences between Treatments. Appendices. References. Indices.

About the Author :
Stefan Wellek is a professor of biostatistics at the University of Heidelberg and head of the Department of Biostatistics at the Central Institute of Mental Health in Mannheim, Germany.

Review :
This book provides a comprehensive and up-to-date overview of the topic and hence, I strongly believe, would be a valuable reference work for a library, and for both applied statisticians who need to deal with equivalence problems and researchers in statistics. Although this is not an introductory textbook, a lot of the material could be used in introductory inference courses. Senior and graduate statistical students would also benefit from exposure to the topic of the book. --Australian & New Zealand Journal of Statistics, 53(1), 2011 ! The update is timely and includes some material on new subjects as well as updates of material presented in the original edition. ! this book deserves a place on the bookshelf of the library of every pharmaceutical company. ! this book remains the standard for texts on equivalence studies. The addition of information on non-inferiority analyses is welcome. A copy of this book should be available to every statistician who works on clinical trials. --Brian Wiens, Alcon Laboratories, Inc., Journal of Biopharmaceutical Statistics, Issue 3, 2011 Praise for the First Edition One of the "Top Five Books for Statisticians" by the JASA/TAS Review Editor --Amstat News, The Membership Magazine of the American Statistical Association, September 2003 The main value of the book is in its rather comprehensive and explicit treatment of various tests for equivalence problems. The book is very carefully written and mathematically correct ! applied (bio-)statisticians may find this book a helpful manual for various testing procedures in the field of equivalence testing. These procedures are very carefully described and are accompanied by SAS of Fortran code. More mathematically oriented readers may regard this book as a good source of examples, and the thorough discussion of relevant practical questions in the field might stimulate them to doing further research in this area. --Journal of the American Statistical Association, March 2004 The book is well organized for the applied statistician with an interest in the theoretical background for statistical procedures. What is especially useful about this book for the applied statistician is that the author weaves into the presentation of the equivalence tests, discussions of power, and sample size as well as simulation results that evaluate the small sample properties of the tests. In addition, a location on the World Wide Web where one can find SAS programs to facilitate the implementation of these tests is provided ! Wellek has provided a text on equivalence testing that the applied statistician will find useful both as a theory underlying equivalence testing as well as a source of equivalence tests and tools for their implementation for a wide variety of situations. --Journal of Biopharmaceutical Statistics ! a thorough and wide-ranging exposition of statistical methods for the testing of hypotheses of equivalence ! The content of the book and the presentation of the material are praiseworthy for several reasons. Throughout the book, the focus is on optimal tests ! . Where exact methods are not available, asymptotically equivalent tests are presented. The small sample behaviour, both size and power, of asymptotic tests is thoroughly studied through simulation. This must have been an enormous amount of work, but the effort certainly was not in vain; one is convinced that one can apply the methods presented with confidence. Even more deserving of praise is the fact that computer programs (mostly in SAS language) implementing various tests and power calculations are provided ! In summary, this is an excellent book and strongly recommended. It is required reading for all biostatisticians and developers of statistical software who work in this arena. It will be useful when teaching statistical test theory and in practice. ! --Robert Schall, Clinical Trials, 2004 ! this book provides the reader with the opportunity to do equivalence testing for various statistical problems. The author has helpfully provided a collection of computer programs (in SAS and Fortran) that allow for easy implementation of the methods presented ! I was left feeling that this book provides a good grounding in statistical techniques to do hypothesis testing in equivalence trials. --Pharmaceutical Statistics, 2003 Wellek has done a commendable service to the academic community by providing the first comprehensive treatment of testing hypotheses of equivalence, since most of the work in this area so far is confined to research journals. ! Overall, this excellent book has great potential for applications and should interest students and researchers alike. Summing Up: Highly recommended. --D.V. Chopra, CHOICE ! this book has explained well with examples and case studies the topics ! Researchers will find this book thought-provoking. --Journal of Statistical Computation & Simulation


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Product Details
  • ISBN-13: 9781439808191
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: Chapman & Hall/CRC
  • Language: English
  • ISBN-10: 1439808198
  • Publisher Date: 24 Jun 2010
  • Binding: Digital (delivered electronically)


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