Toxicology: Principles and Applications

Focusing primarily on basic principles and concepts, Toxicology also provides 200 tables worth of toxicological data. Each heavily illustrated chapter is a complete study unit containing a table of contents, an introduction, a learning core, a self-test, and feedback. The main text for the unit is followed by a self-test, which reveals whether the learning objectives have been met. The feedback section answers frequently asked questions, while a summary enables the student to review the main concepts before moving on to the next unit.

Table of Contents:
FUNDAMENTAL PRINCIPLES Toxicology: History and Scope of the Field, J.H. Koeman Exposure: Qualitative and Quantitative Aspects, A. Musch Biotransformation: Detoxification and Bioactivation, B.J. Blaauboer Biotransformation: Species Differences and Determining Factors, A. Bast Absorption, Distribution, and Elimination of Xenobiotics, R.J.M. Niesink Toxicokinetics: Quantitative Aspects, J. de Vries Dose-time-effect Relationships, A. Musch MOLECULAR ASPECTS OF TOXICITY Structure-activity Relationships, J.L.M. Hermens Toxicity of Mixtures, A. Musch Cytotoxicity: Molecular Mechanisms of Cell Death, J. de Vries Genetic Toxicology, Ph. Vanparys and F.-J. van Schooten Introduction to Carcinogenesis, H. van Cauteren, Th.M.C.M. de Kok, and F.-J. van Schooten Cancer Risk Evaluation, H. van Cauteren, Th.M.C.M. de Kok, and F.-J. van Schooten ORGAN TOXICOLOGY Toxicity Testing, Risk Assessment, Regulation, and Legislation, K.N. Woodward Cytopathology: General Response Patterns and Morphological Aspects, A. Penninks Necrosis and Apoptosis: Irreversibility of Cell Damage and Cell Death, A. Verheyen ORGANS INVOLVED IN ABSORPTION AND ELIMINATION Dermatotoxicology: Toxicological Pathology and Methodological Aspects, R.J.M. Niesink Respiratory Toxicology: Pathophysiology, Toxicological Pathology, and Mechanisms of Toxicity, R.B. Beems, V.J. Feron, P.G.J. Reuzel, and A. Zwart Inhalatory Exposure and Methodological Aspects, R.B. Beems, V.J. Feron, P.G.J. Reuzel, and A. Zwart Gastro-intestinal Toxicology: Structure, Function, and Intestinal Toxicity, W. Coussement Gastro-intestinal Toxicology: Toxicological Pathology and Sources of Intestinal Toxicity, W. Coussement Hepatotoxicology: Structure, Function, and Toxicological Pathology, J. Vandenberghe Hepatotoxicology: Mechanisms of Liver Toxicity and Methodological Aspects, J. Vandenberghe Nephrotoxicology: Toxicological Pathology and Biochemical Toxicology, J.F. Nagelkerke Organ Perfusion Techniques: In Vitro Toxicity Testing, A. Sj. Koster ORGANS INVOLVED IN MAINTAINING HOMEOSTASIS Cardiovascular Toxicology: Toxicological Pathology and Methodological Aspects, A. Verheyen Toxicology of the Blood: Pathophysiology, Toxicological Pathology, and Mechanistic Aspects, J.J. Marx Immunotoxicology: Determination of Immunotoxic Effects and Immunotoxicity Mechanisms, H. van Loveren and J.G. Vos Immunotoxicology: Examples of Immunotoxic Substances, H. van Loveren and J.G. Vos Endocrinotoxicology: Methodological Aspects, M.A.M. Krajns-Franken, F.X.R. van Leeuwen, and J.G. Loeber General Reproductive Toxicology, J.M. Garbis-Berkvens, P.W.J. Peters Special Reproductive Toxicology, J.M. Garbis-Berkvens and P.W.J. Peters Anatomy and Toxicological Pathology of the Nervous System, A. Bast Functional Neurotoxicology, T.A. de Vlieger Neurobehavioral Toxicology, R.J.M. Niesink APPLICATION AREAS Introduction to Nutritional Toxicology, J.H. Koeman Food Toxicity: The Toxicological History of Aspartame, J.C.S. Kleinjans Medical and Clinical Toxicology, B. Sangster Ecotoxicology, N.M. van Straalen Occupational Toxicology, P.J.A. Borm and P.Th. Henderson Achievement Test Abbreviations Formula Index Glossary of Terms Literature Index