About the Book
Shaped by Quantum Theory, Technology, and the Genomics Revolution
The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers.
Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians
Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies.
What’s New in This Edition:
A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including:
Fiber Optic Probe Design
Laser and Optical Radiation Safety
Photothermal Detection
Multidimensional Fluorescence Imaging
Surface Plasmon Resonance Imaging
Molecular Contrast Optical Coherence Tomography
Multiscale Photoacoustics
Polarized Light for Medical Diagnostics
Quantitative Diffuse Reflectance Imaging
Interferometric Light Scattering
Nonlinear Interferometric Vibrational Imaging
Multimodality Theranostics Nanoplatforms
Nanoscintillator-Based Therapy
SERS Molecular Sentinel Nanoprobes
Plasmonic Coupling Interference Nanoprobes
Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.
Table of Contents:
Volume One: Photonics and Tissue Optics. Optical Properties of Tissues. Light-Tissue Interactions. Theoretical Models and Algorithms in Optical Diffusion Tomography. Basic Instrumentation. Basic Instrumentation in Photonics. Optical Fibers and Waveguides for Medical Applications. Fiberoptics Probe Design. Laser and Optical Radiation Safety in Biophotonics. Photonic Detection and Imaging Techniques. Biological Imaging Spectroscopy. Lifetime-Based Imaging. Confocal Microscopy. Two-Photon Excitation Fluorescence Microscopy. Laser Doppler Perfusion Monitoring and Imaging. Light Scatter Spectroscopy and Imaging of Cellular and Subcellular Events. Tissue Viability Imaging. Photothermal Detection and Tracking of Individual Non-fluorescent Nanosystems. Thermal Imaging. Multidimensional fluorescence imaging of biological tissue. Speckle Correlometry. Spectroscopic Data in Biological and Biomedical Analysis
Volume Two: Biomedical Analysis, Sensing and Imaging. Biosensors for Medical Applications. Glucose Monitoring. Biochips and MicroArrays: Tools for the New Medicine. Atomic Spectroscopy for Biological and Clinical Analysis. Flow Cytometry. Capillary Electrophoresis Techniques in Biomedical Analysis. Surface Plasmon Resonance Imaging: Principle, Development, and Biomedical Applications. Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics. Functional Imaging with Diffusing Light. Molecular Contrast Optical Coherence Tomography. Multiscale Photoacoustic Microscopy and Macroscopy. Polarized light for Medical Diagnostics. Optical Pumping and MRI of Hyperpolarized Spins. Biomedical Diagnostics and Optical Biopsy. Fluorescence Spectroscopy for Biomedical Diagnostics. Elastic-Scattering Spectroscopy and Diffuse Reflectance. Quantitative Diffuse Reflectance Imaging of Tumor Margins. Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues. Interferometric light scattering techniques for measuring nuclear morphology and detecting dysplasia. Ultrasonically Modulated Optical Imaging. Optoacoustic Tomography. Raman Spectroscopy: From Benchtop to Bedside. Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging. Photon Migration Spectroscopy Frequency-Domain Techniques.
Volume Three: Therapeutic and Interventional Techniques. Mechanistic Principles of Photodynamic Therapy. Synthesis and Biological Significance of Porphyrin-based Photosensitizers in Photodynamic Therapy. Lasers in Dermatology. Lasers in Interventional Pulmonology. Lasers in Diagnostics and Treatment of Brain Diseases. Lasers in Ophthalmology. Lasers in Otolaryngology. Therapeutic Applications of Lasers in Gastroenterology. Low-Power Laser Therapy. Image Guided Surgery. Optical Methods for Caries Detection, Diagnosis and Therapeutic Intervention. Nonlinear Interferometric Vibrational Imaging and Spectroscopy. Multifunctional Theranostic Platform: Plasmonic-Active Gold Nanostars. Activity of psoralen-functionalized nanoscintillators against cancer cells upon X-ray excitation. Advanced Biophotonics and Nanophotonics . Living Cell Analysis Using Optical Methods. Amplification Techniques for Optical Detection. Fluorescent Probes in Biomedical Applications. Optical Trapping Techniques in Bioanalysis, . Luminescent Nanoparticle-Based Probes for Bioassays, . Fluorescent Molecular Beacon Nucleic Acid Probes for Biomolecular Recognition. Luminescent Quantum Dots for Diagnositc and Bioimaging Applications. PEBBLE nanosensors for in vitro bioanalysis. Nanosensors for Single-Cell Analyses. SERS Molecular Sentinel Nanoprobes to Detect Biomarkers for Medical Diagnostics. Plasmonic Coupling Interference (PCI) Nanoprobes for Gene Diagnostics. DNA Sequencing using Fluorescence Detection. In Vivo Bioluminescence Imaging as a Tool for Drug Development.
Review :
"Excellent book! Sheds new, latest and important light on the field of biomedical photonics. The second edition has put together a comprehensive resource covering all aspects of photonics in the field of biomedicine under three volumes. The use of practical examples summarizing real-world examples by scientists and engineers allows a collective look into the current best practices. This book will be valuable to anyone seeking to understand the complexities of designing fiber optic instruments, techniques involved behind analysis, diagnostics nuances and therapeutic modalities. Students and practitioners will learn about the latest tools and techniques used by leading researchers, scientists and engineers. A great compilation of varied research fields in the area of Biophotonics. Especially, a great reference book as topics are effectively dealt in-depth with lots of citations after each chapter."
—Dr. Shanthi Prince, SRM University, India
"No one has, or ever will, attempt to create such a comprehensive text in this field. It is an enormous undertaking that we are all grateful to have, but would not want to do it ourselves."
—Christopher H. Contag, Stanford University, California, USA
"… extensive and comprehensive coverage, resulting in an additional two volumes of material in this new edition … [containing] the latest research and technology in biomedical optics/photonics."
—Inci Cilesiz, Istanbul Technical University, Turkey
"I like the breadth of topics, particularly the fact that they cover fundamental issues as well as advanced research areas. … exhaustive coverage of biomedical optics starting from the very basic fundamentals to a wide variety of cutting-edge concepts. This makes the text ideal for all levels of readers—from undergraduate students to senior researchers."
—Kartikeya Murari, University of Calgary, Alberta, Canada
"… written in a clear language providing an easy transaction from the basic and fundamental concepts to expert level topics. This approach makes these materials very suitable for academic purposes. … an excellent reference book for the researcher, teacher, and student. It provides a detailed and up-to-date expert coverage of fundamental concepts and current biomedical photonics techniques and applications. It also addresses several frontier research topics and emergent technologies that will surely result in future applications."
—António Miguel Morgado, University of Coimbra, Portugal
"This handbook is a step ahead in the sense that it brings together the recent advances in various fields of biomedical photonics. [It] serves as a teaching reference as well as a research guide."
—Renu John, Indian Institute of Technology Hyderabad, Telangana
