Foundations of Cardiac Arrhythmias: Basic Concepts and Clinical Approaches(Fundamental and Clinical Cardiology)

This single-source reference/text is an authoritative, up-to-date, and multidisciplinary presentation of basic, applied, and clinical approaches to the diagnosis, treatment, and management of cardiac arrhythmia and the prevention of sudden cardiac death-providing essential concepts for new approaches to pharmacologic and electrical therapies. Over 50 leading physicians, scientists, and engineers integrate their research knowledge into a solid foundation of fundamentals in innovative new ways to promote an understanding of cardiac arrhythmias on a multilevel basis that spans the full range of topics from genes to therapy prevention. From the regular rhythm of the heart to the irregular, chaotic states that characterize fibrillation and tachyarrhythmias, Foundations of Cardiac Arrhythmias explores the ionic and molecular basis of electrogenesis and its control within different types of cardiac cells clarifies the molecular and biochemical regulation of cell-to-cell conduction that will help facilitate development of the next generation of antiarrhythmic drugs considers genetic determinants that influence the onset of sudden death in rare and acquired heart disease explores recent insights into macroscopic, three-dimensional interactions implicated in the genesis of malignant ventricular tachycardias surveys population studies that reveal new information about the relevance of higher frequency polymorphisms and variations in molecules involved in cardiac control discusses the role of cardiac ablation and the use of pacemakers and defibrillators, including new concepts in device design discusses promising new advances with noninvasive markers of arrhythmia risk that are helping to identify patients at risk for sudden death Containing nearly 2300 key literature citations and over 300 helpful drawings, photographs, equations, and tables, Foundations of Cardiac Arrhythmias serves as a thorough and inspiring reference for clinical and research cardiologists, clinical and basic electrophysiologists, pharmacologists, molecular and cell physiologists, biologists, biochemists, molecular geneticists, biomedical and electrical engineers, and biophysicists, as well as an important text for graduate students, residents, and fellows in these disciplines.

Table of Contents:
Perspectives on Arrhythmogenesis; Antiarrhythmic Strategies; and Sudden Cardiac Death Peter M. Spooner and Michael R. Rosen Ion Channels to Action Potentials Cardiac Membrane and Action Potentials Dan M. Roden Cardiac Ion Channels Harry A. Fozzard Cardiac Ion Pumps and Ion Exchangers Arnold Schwartz and Denis Noble Regulation of Cardiac Ion Channels and Transporters H. Criss Hartzell and Arnold M. Katz Molecular Diversity and Distribution of Cardiac Ion Channels Harold C. Strauss and Arthur M. Brown Action Potentials to Tissue Activation Sinoatrial Node and Impulse Initiation Richard B. Robinson and Dario DiFrancesco Intracardiac Cell Communication and Gap Junctions Jeffrey E. Saffitz and Mark J. Yeager Impulse Conduction: Continuous and Discontinuous Charles Antzelevitch and Madison S. Spach Networks: Fundamental Properties and Models Ronald W. Joyner and André G Kléber Atrioventricular Conduction Ralph Lazzara; Benjamin J. Scherlag; and Luiz Belardinelli Ca2+ and Arrhythmias Henk E .D. J. ter Keurs and Penelope A. Boyden Tissue Activation to Cardiac Rhythm The Electrocardiogram and Electrophysiological Analysis David M. Mirvis and Robert Plonsey Global Behaviors of Cardiac Activation Yoram Rudy and José Jalife Mapping and Invasive Analysis Robert L. Lux; Masood Akhtar; and Robert S. MacLeod Arrhythmias: Origins and Mechanisms Automaticity and Triggered Activity Marc A. Vos and Bruce B. Lerman Reentry Michiel J. Janse and Eugene Downar Atrial Fibrillation Albert L. Waldo and David R. Van Wagoner Ventricular Fibrillation and Defibrillation Stephen M. Dillon and Richard A. Gray Origins; Classification; and Significance of Ventricular Arrhythmias Robert J. Myerburg; Heikki V. Huikuri; and Agustin Castellanos Therapeutic Strategies and Future Directions Cardiac Pacemakers Adam Zivin; Rahul Mehra; and Gust H. Bardy Implantable Cardioverter Defibrillators Adam Zivin; Rahul Mehra; and Gust H. Bardy Remodeling: Structural and Electrical Considerations Gordon F. Tomaselli and Karl T. Weber Transgenic Electrophysiology and Small Animal Models Amit Rakhit and Charles I. Berul Genetic Approaches and Familial Arrhythmias Jeffrey A. Towbin and Ketty Schwartz New Directions for Arrhythmic Drug Development Based on Molecular Approaches to Arrhythmogenesis Eduardo Marbán and Michael Sanguinetti Ablation Therapy of Cardiac Arrhythmias Douglas P. Zipes Risk Identification by Noninvasive Markers of Cardiac Vulnerability Richard L. Verrier and Richard J. Cohen Sudden Cardiac Death and Its Prevention Christine M.. Albert; Leonard A. Cobb; and Jeremy N. Ruskin