Combinatorial Synthesis of Natural Product-Based Libraries
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Combinatorial Synthesis of Natural Product-Based Libraries

Combinatorial Synthesis of Natural Product-Based Libraries


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About the Book

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Table of Contents:
Chemistry on the Interface of Natural Products and Combinatorial Chemistry. Natural Products and Combinatorial Chemistry: An Uneasy Past but a Glorious Future. Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product-Based Compound Libraries. Accessing Expanded Molecular Diversity Through Engineered Biosynthesis of Natural Products. Natural Product-Based Chemically and Functionally Diverse Libraries. The Use of Polymer-Supported Reagents and Scavengers in the Synthesis of Natural Products. Carbohydrate-Derived Small Molecule Libraries. In Search of Novel Antibiotics Using a Natural Products Template Approach. Synthetic Libraries of Fungal Natural Products. Solid-Phase Combinatorial Synthesis Based on Natural Products. Natural Product-Like Combinatorial Libraries Toward the Discovery of Lead Compounds.

About the Author :
Armen M. Boldi received his B.A. degree in chemistry from Occidental College in Los Angeles, California. He earned his Ph.D. in chemistry from the University of California at Los Angeles (UCLA), working with François Diederich. He went on to the University of Pennsylvania to work as a National Institutes of Health (NIH) postdoctoral fellow with Amos B. Smith, III, on the total synthesis of the spongistatins. In 1997, he joined the drug discovery efforts of Arris Pharmaceutical (now Applera Corporation–Celera Genomics Group) in the combinatorial chemistry group. Dr. Boldi was actively involved with the development and growth of this group, which developed first into a division and subsequently into a wholly owned subsidiary. The combinatorial chemistry business unit located in South San Francisco was subsequently acquired by Discovery Partners International in 2001. He continued to work at Discovery Partners International in the chemistry division on numerous library programs with pharmaceutical and biotech companies in the United States, Europe, and Japan. Acting as director of project management, he managed various synthetic chemistry collaborations. He recently moved to Codexis, Inc., Redwood City, California, to serve as manager of research and development operations. For the past nine years, his group has focused on the development and the application of synthetic methodologies to the generation of discovery libraries and targeted libraries for lead identification. His research interests span the various disciplines in the drug discovery process including medicinal, combinatorial, and synthetic chemistry. He has a special interest in integrating small-molecule natural product-based libraries into lead discovery programs. Dr. Boldi has published over 20 technical papers in the areas of synthetic organic chemistry and combinatorial chemistry.

Review :
"[This book] elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the historical developments to the latest technologies, from the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...A huge amount of references give the readers the opportunity to return to the original papers... ... A large amount of appealing Figures and Schemes illustrate the concepts discussed in the text. The Chapters are well structured... As the authors are from different backgrounds, the book covers various strategies, various synthetic methods, and all types of compound families. ...[A] valuable tool for everybody working in medicinal chemistry as well as the agrochemical, industrial, or academic domains. - François Diederich, Swiss Federal Institute of Technology, Zurich "...Elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ..." - François Diederich, Swiss Federal Institute of Technology, Zurich "A first-rate source of information to learn about different planning strategies" -Victor E. Marquez in Journal of Medicinal Chemistry 2007, Vol. 50, No. 5 (2007)


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Product Details
  • ISBN-13: 9781420009279
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Language: English
  • ISBN-10: 1420009273
  • Publisher Date: 16 May 2006
  • Binding: Digital (delivered electronically)


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