The Demon Under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In" The Demon Under the Microscope," Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine. Sulfa saved millions of lives--among them those of Winston Churchill and Franklin Delano Roosevelt Jr.--but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, " The Demon Under the Microscope" illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia--pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis--were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . . But all that was about to change. . . . --from "The Demon Under the Microscope"

Review :
"Fascinating . . . A rousing, valuable contribution to the history of medicine." -"Kirkus Reviews" (Starred) "A well-told tale of trail-blazing science." -"Booklist " "Highly recommended." -"Library Science" "This is a grand story, and Mr. Hager tells it well...one can easily imagine 'The Demon Under the Microscope, ' like 'Microbe Hunters' before it, inspiring in young, idealistic readers the enthusiasm for medical research and the zeal for healing that generates great physicians." -"Wall Street Journal" "Surprisingly entertaining...[Hager's] enthusiasm for the search for a 'magic bullet' drug in the early 20th century is infectious. He convincingly credits sulfa drugs for some of the most revolutionary and catastrophic moments in medicine. And anecdotes about famous people affected- from Calvin Coolidge to Eleanor Roosevelt- are narrative spoonfuls of sugar." -"Entertainment Weekly" "Grips the reader from the first paragraph...a story of dedication, luck, tragedy and triumph that's still relevant today." -"Bookpage" "Hager, a biographer of Linus Pauling, does a remarkable job of transforming material fit for a graduate biology seminar into highly entertaining reading. He knows that lay readers need plenty of personality and local color, and his story is rich with both. This yarn prefigures the modern rush for corporate pharma patents; it is testament to Hager's skills that the inherently unsexy process of finding the chemicals that might help conquer strep is as exciting an account of the hunt for a Russian submarine." -"Publishers Weekly"