Unlock the potential of the intersection of additive manufacturing and biomedicine with this essential guide, which provides a comprehensive look at the applications, challenges, and industrial advancements of biomaterials for industrial processes.
The sustainability of any process lies in how eco-friendly and economical its products are. Bio-based materials of different origins are emerging as a sustainable option for raw materials for different products with diverse applications. The book highlights the fabrication of implants, scaffolds, and biomedical devices based on naturally sourced biobased materials, with coverage that includes: Emerging biobased composites for orthopedic, soft tissue, and hard tissue engineering; An in-depth study of the latest emerging manufacturing process and resorbable materials for biomedical applications; Biological and degradation studies, along with challenges associated with resorbable implants; Special chapters on artificial organ development through additive manufacturing and their processing; Challenges in additive manufacturing related to processing and cost-effectiveness of resorbable polymeric implants.
Readers will find the volume:
- Focuses on the practical application of 3D printing in medicine, covering areas like implants, prosthetics, drug delivery, and tissue engineering;
- Explores the crucial aspects of materials science and process optimization necessary for successful biomedical additive manufacturing;
- Addresses the growing trend of personalized medicine enabled by patient-specific 3D-printed scaffolds and implants;
- Provides detailed studies on chitosan, PCL, alginate, and cellulose biomaterials as feedstock for additive manufacturing using composites;
- Discusses the challenges and industrial advancements driving the adoption of additive manufacturing in the biomedical sector.
Audience
Academics, practitioners, polymer scientists, biomedical and mechanical engineers, materials scientists, and researchers working in the areas of additive manufacturing in biomedical applications.
Table of Contents:
Preface xxvii
Acknowledgement xxix
Part I: Fundamentals of Additive Manufacturing in Healthcare 1
1 Introduction to Additive Manufacturing for Healthcare Applications 3
Arbind Prasad and Ranjit Barua
1.1 Introduction 4
1.2 History and Background 5
1.3 AM Technology and Method 6
1.4 Additive Manufacturing in Medical Applications 8
1.5 Recent Challenges and Future Directions of Healthcare Enabled by AM 12
1.6 Future Possibilities 15
1.7 Conclusion 16
2 Materials and Processing in Additive Manufacturing for Healthcare Applications 25
Atanu Kumar Paul, Gourhari Chakraborty and Arbind Prasad
2.1 Introduction 26
2.2 Materials for Additive Manufacturing in Healthcare 29
2.3 Processing Techniques in Additive Manufacturing 31
2.4 Applications of Additive Manufacturing in Healthcare 38
2.5 Key Areas of Potential Enhancement in Clinical Performance and Functionality 42
2.6 Challenges and Future Perspectives 44
2.7 Key Themes in Integration of Materials and Processing 47
2.8 Case Studies and Applications 50
2.9 Conclusions 52
Part II: Materials for Additive Manufacturing in Healthcare 63
3 Biopolymer-Based Biomaterials as Feedstock Materials for Additive Manufacturing 65
Magdalena B. Labowska, Adrianna Cieslak, Maria Skrodzka, Patrycja Szymczyk-Ziolkowska, Agnieszka Adamczyk and Jerzy Detyna
3.1 Introduction 66
3.2 Types of Biopolymers Used in Additive Manufacturing Technologies 68
3.3 Techniques of Additive Manufacturing for Biomedical Applications 75
3.4 Challenges in Using Biopolymers for Additive Manufacturing Technologies 81
3.5 Medical Application of Biopolymers 82
3.6 Future Research Directions and Perspectives 86
3.7 Conclusions 88
4 3D-Printed Biopolymeric Scaffolds and Implants 99
Kinga Sekula, Maja Ducka, Grzegorz Ziolkowski, Jerzy Detyna and Patrycja Szymczyk-Ziolkowska
4.1 Introduction 100
4.2 Classification of Biopolymers 102
4.3 Emerging Biopolymers, Hybrids, or Blends 111
4.4 Biopolymers Use in 3D Printing 112
4.5 Additive Manufacturing of Biopolymeric Scaffolds and Implants 113
4.6 Applications of Biopolymers in Medicine 120
4.7 Conclusion 126
5 Additive Manufacturing of PLA-Based Biocomposites for Biomedical Applications 137
Ranjit Barua, Sumit Bhowmik, Deepanjan Das and Sudipto Datta
5.1 Introduction 138
5.2 3D Printing Techniques for PLA 139
5.3 PLA-Based Biomaterials 141
5.4 Applications of PLA in Biomedical Fields 142
5.5 Innovations and Future Directions 144
5.6 Biodegradation and Biocompatibility of PLA 147
5.7 Challenges and Limitations 148
5.8 Future Directions and Innovations 149
5.9 Conclusion 149
6 Cellulose-Based Biomaterial in Additive Manufacturing 155
Siddharth Mohan Bhasney, Rhia Madhuri, Bidyanand Mahto and Arbind Prasad
6.1 Background History and Introduction 156
6.2 Latest Developments 158
6.3 Biopolymers and Types 166
6.4 3D Printing—Suitable Properties for Biomaterials 168
6.5 Cellular Techniques 171
6.6 Materials and Method 182
6.7 Conclusion 191
7 Chitosan-Based Composites in Additive Manufacturing Process 205
Vishnuvarthanan Mayakrishnan and Raja Venkatesan
7.1 Introduction 206
7.2 Overview of Chitosan 207
7.3 Biocompatibility of Chitosan 210
7.4 Antimicrobial Activity of Chitosan 212
7.5 Fabrication of Chitosan-Based Composites Using Additive Manufacturing 214
7.6 Incorporation of Additives and Reinforcements 219
7.7 Biomedical Applications of Chitosan-Based Composites 222
7.8 Customization via Additive Manufacturing Techniques 226
7.9 Potential of Chitosan-Based Composites in Biomedical Applications 228
7.10 Future Research Directions and Challenges 231
7.11 Conclusion 233
8 Silk Fibroin-Based Composites in Additive Manufacturing Process 239
Shubham Pant, Syed Fathima Missriya, Sravanthi Loganathan and Ravi Babu Valapa
8.1 Introduction 240
8.2 Background of SF Types for Additive Manufacturing 241
8.3 Additive Manufacturing Techniques for SF 244
8.4 Applications of SF in Additive Manufacturing 248
8.5 Challenges and Future Prospective 261
8.6 Conclusion 262
9 Additively Manufactured PCL-Based Bio-Composites for Biomedical Applications 273
Varatharajan Prasannavenkadesan, Syed Naveed Ul Meiraj, Ram Prasanth S. and J. Jeevamalar
9.1 Introduction 273
9.2 Applications in Tissue Engineering 278
9.3 Applications in Medical Devices 283
9.4 Dental Applications 287
9.5 Summary 287
10 Polylactic-Co-Glycolic Acid (PLGA)-Based Composites through Additive Manufacturing Techniques for Biomedical Applications 295
Ranjit Barua, Arbind Prasad and Sudipto Datta
10.1 Introduction 296
10.2 Properties of PLGA for Biomedical Applications 297
10.3 PLGA-Based Composite Formulations 299
10.4 Additive Manufacturing Techniques for PLGA Composites 300
10.5 Biomedical Applications of PLGA-Based Composites 301
10.6 Challenges and Future Directions 301
10.7 Future Directions 302
10.8 Conclusion 303
11 Alginate-Based Composites in Additive Manufacturing 309
Ilangovan Pugazhenthi and Vishnu Kirthi Arivarasan
11.1 Introduction 310
11.2 Alginate Composites for Additive Manufacturing 312
11.3 3D Printing Techniques 317
11.4 Applications of Alginate-Composite-Based Bioink Uses in Tissue Engineering 323
11.5 Limitations, Advantages, and Prospects of Printed Alginate-Based Materials 327
11.6 Conclusion 328
Part III: Applications and Future Directions 337
12 3D Printing in Hard Tissue Engineering 339
Ranjit Barua, Arbind Prasad, Bidyanand Mahto and Sudipto Datta
12.1 Introduction 340
12.2 Materials Used in 3D Printing for Hard Tissue Engineering 342
12.3 3D Printing Techniques in Hard Tissue Engineering 346
12.4 Design and Fabrication of Scaffolds 349
12.5 Applications in Bone Tissue Engineering 353
12.6 Clinical Challenges and Solutions 356
12.7 Future Directions and Conclusion 360
12.8 Conclusion 362
13 3D Printing in Drug Delivery Applications 369
Awadhesh Kumar Verma, Nisha Shankhwar, Tanya Singh, Satyendra Singh and Neeta Raj Sharma
13.1 Introduction 370
13.2 3D Printing Techniques for Drug Delivery 372
13.3 Applications of 3D Printing in Drug Delivery 378
13.4 Materials for 3D-Printed Drug Delivery Systems 386
13.5 Design Considerations for 3D-Printed Drug Delivery Devices 393
13.6 Preclinical and Clinical Studies of 3D-Printed Drug Delivery Systems 395
13.7 Challenges and Future Directions 397
13.8 Conclusion 399
14 Next-Gen Bioprinting: Transforming Medicine with PLA Biocomposites 407
Maneesh Dubey, Ruchin Kacker, Sanjay Kumar Singh and Amit Arora
14.1 Introduction 408
14.2 Polylactic Acid (PLA) in Biomedical Applications 413
14.3 Biocomposites for Biomedical Applications 417
14.4 Additive Manufacturing of PLA-Based Biocomposites 421
14.5 Characterization of PLA-Based Biocomposites 425
14.6 Scaffolds for Tissue Engineering 429
14.7 Applications in Drug Delivery Systems 432
14.8 Regulatory and Ethical Considerations 435
14.9 Advances in AM Technologies for Biocomposites 437
14.10 Conclusion and Summary 439
15 Advances in Biological Studies of Additively Manufactured Biomaterials 449
Arindam Banerjee, Debasish Banerjee and Sudipto Datta
15.1 Introduction 450
15.2 The Evolution of Additive Manufacturing in Biomaterials Science 451
15.3 Advances in Biocompatibility and Biofunctionality 452
15.4 Advances in Bioprinting and Tissue Engineering 454
15.5 Development of Bioinks 456
15.6 Bioinks for Vascularized Tissue Engineering 458
15.7 Applications in Tissue Engineering 459
15.8 Challenges and Future Directions 468
15.9 Conclusion 468
16 Degradation Studies of Additive Manufactured Biomedical Devices 475
Subhasree Panda, Vipu Vinayak V.J., Jameer Basha S.K., Thangamani Jayaram Gounder, Mohan Kumar Kesarla and S.K. Khadheer Pasha
16.1 Introduction 476
16.2 A Brief Survey on AM 477
16.3 Additive Manufacturing of Biomaterials 479
16.4 Biomedical Applications of AM-Based Biomaterials 481
16.5 Degradation Studies of AM-Based Biomedical Devices 486
16.6 Conclusion 499
17 Challenges and Perspective Applications of Additive Manufacturing in Biomedical Applications 505
Santosh Kumar and Rakesh Kumar
17.1 Introduction 506
17.2 State-of-The-Art in AM for Biomedical Applications 510
17.3 Challenges in AM for Biomedical Applications 518
17.4 Future Perspectives and Emerging Trends 520
17.5 Conclusion 522
References 523
Index 533
About the Author :
Arbind Prasad, PhD is an Assistant Professor and the Head of Mechanical Engineering Department, Katihar Engineering College (Under Department of Science, Technology and?Technical Education, Government of Bihar), Katihar, Bihar, India. He has published 20+ journal articles, 16 books, 48 book chapters, and 15 conference papers. His research spans resorbable polymers, biomaterials, and nanomaterials processing.
Vimal Katiyar, PhD is a Professor in the Chemical Engineering Department at the Indian Institute of Technology, Guwahati, Assam, India. He has published more than 180 articles in reputed international journals, edited six books, and holds 29 patents. His research focuses on nanocomposites and polymerization.
