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Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Dentistry > Allogeneic Bone Grafts Mixed with Basic Fibroblast Growth Factor: A Cellular and Molecular Study
Allogeneic Bone Grafts Mixed with Basic Fibroblast Growth Factor: A Cellular and Molecular Study

Allogeneic Bone Grafts Mixed with Basic Fibroblast Growth Factor: A Cellular and Molecular Study


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About the Book

This dissertation, "Allogeneic Bone Grafts Mixed With Basic Fibroblast Growth Factor: a Cellular and Molecular Study" by 陸梅, Mei, Lu, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Allogeneic Bone Grafts Mixed with Basic Fibroblast Growth Factor: A Cellular and Molecular Study submitted by Mei Lu for the degree of Doctor of Philosophy at The University of Hong Kong in December 2002 This study was designed to develop a totally allogeneic bone graft that would eliminate the need for harvesting autogenous bone from the patients. This allogeneic graft material consisted of allogeneic intramembranous (IM) bone and basic fibroblast growth factor (bFGF) reconstituted in demineralized bone matrix prepared from intramembranous bone (DBM ). Further objectives of the current study were: IM - To elucidate the cellular and molecular mechanism by which bFGF augments the osteoinductivity of allogeneic IM bone grafts. - To identify the cells involved in the healing of this composite allogeneic bone grafts. - To examine the factors involved in resorption of allogeneic bone grafts and compared it to autogenous bone. - To examine the microarchitecture of autogenous bone grafts in three- dimensions. Eighty-four critical size (15 10 mm) defects were created on rabbit mandibles bilaterally. Five groups of twelve defects each were respectively grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, allogeneic IM bone alone, allogeneic IM bone and DBM powder, and allogeneic IM IM bone and bFGF reconstituted in DBM powder. The remaining defects were used as IM controls. Animals were killed at three weeks and three months postgrafting. The defects were retrieved for histology, transmission electron microscopy, micro- computed tomography, immunohistochemistry and in situ hybridization. Quantitative analysis was performed using an image analyzer. No bone formed across the defect in controls. Composite allogeneic IM bone-bFGF- DBM graft produced 550% more new bone than did allogeneic IM bone alone 3 IM weeks postgrafting (p


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Product Details
  • ISBN-13: 9781374728332
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 278
  • Sub Title: A Cellular and Molecular Study
  • Width: 216 mm
  • ISBN-10: 1374728330
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 15 mm
  • Weight: 649 gr


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