Expression of Regulatory Helix-Loop-Helix Factor Id2 Protein in the Developing and Adult Mouse Retina
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Home > Medicine & Health Science textbooks > Pre-clinical medicine: basic sciences > Anatomy > Expression of Regulatory Helix-Loop-Helix Factor Id2 Protein in the Developing and Adult Mouse Retina
Expression of Regulatory Helix-Loop-Helix Factor Id2 Protein in the Developing and Adult Mouse Retina

Expression of Regulatory Helix-Loop-Helix Factor Id2 Protein in the Developing and Adult Mouse Retina


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This dissertation, "Expression of Regulatory Helix-loop-helix Factor Id2 Protein in the Developing and Adult Mouse Retina" by Sze-chun, Yeung, 楊思俊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Expression of Regulatory Helix-loop-helix Factor Id2 protein in the Developing and Adult Mouse Retina" Sumitted by YEUNG Sze Chun for the degree of Master of Philosophy at The University of Hong Kong in August 2004 Id2, as well as other Id proteins, was first identified as an inhibitor of differentiation because it was down-regulated during differentiation and upon cell cycle withdrawal, and up-regulated in proliferative and undifferentiated cells, and that overexpression of Id2 inhibits differentiation. Id2 has been suggested to be of much wider biological roles than merely as negative regulators of cell differentiation. However, analysis of Id2 expression during postnatal development and in the adult has not been well documented. The major goal of my study was to examine the expression pattern of Id2 and to identify cells which selectively and specifically expressed Id2 in the mouse retina during postnatal development and in adulthood. The first part of this study was to investigate the expression pattern of Id2 in the postnatal and adult mouse retina. Mouse retina was chosen for the study because it processes a well-organized laminar structure, and it is anatomically easy to access and manipulate. In this part of my study, the results demonstrated that Id2 expression displayed distinct spatial and temporal patterns in postnatal and adult mouse retina. Id2 has long been considered to be the regulator of cell cycle progression and differentiation, and not just simply as inhibitor of differentiation in the central nervous system. In addition, the subcellular localization of Id2 is believed to be an indicator of function relevance of Id2. However, the identification of Id2 expressing cells in the retina still remains unclear. The present study demonstrated that Id2 was specifically expressed in the amacrine cells and a few bipolar cells, and Id2 expression was restricted in the nuclei of these cells. The final part of my study was to investigate the relative Id2 gene expression level in the mouse retina during postnatal development and in the adult. As Id2 proteins take part in the complex network of neural cellular process, thus, it is important to understand the relative expression level of Id2 in the mouse retina at different postnatal developmental time point. This study showed that the relative level of Id2 mRNA decreased in a biphasic manner in the mouse retina with the progression of postnatal development. One of the important insights in my study is the demonstration of Id2 expression in the postnatal and adult mouse retina. Id2 was expressed at high levels in postmitotic differentiated retinal neurons from the time of birth to adulthood. The coexpression analysis with cell-specific markers indicated that Id2 expressing cells in the inner nuclear layer were mostly amacrine cells and a few bipolar cells. In addition, Id2 mRNA level declined with the postnatal developmental age but remained at a significant level in adult mouse retina. Taken together, these data suggest that Id2 may play a pivotal role in the development and maintenance of specific neural lineages in the mouse retina. DOI: 10.5353/th_b2997664 Subjects: Helix-loop-helix motifs DNA-binding proteins Transcription factors Retina Mice as laboratory animals


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Product Details
  • ISBN-13: 9781374721517
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 94
  • Weight: 513 gr
  • ISBN-10: 1374721514
  • Publisher Date: 27 Jan 2017
  • Binding: Hardback
  • Language: English
  • Spine Width: 6 mm
  • Width: 216 mm


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