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Regulatory and Functional Study of Human Cytoglobin

Regulatory and Functional Study of Human Cytoglobin


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About the Book

This dissertation, "Regulatory and Functional Study of Human Cytoglobin" by Xiumei, Guo, 郭秀梅, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled REGULATORY AND FUNCTIONAL STUDY OF HUMAN CYTOGLOBIN Submitted by Guo Xiumei for the degree of Doctor of Philosophy at The University of Hong Kong in April 2007 Cytoglobin (CYGB) is a new member of the vertebrate globin family which encompasses hemoglobin, myoglobin and neuroglobin. Although the physiological function of CYGB is still unclear, spectroscopic studies show that CYGB contains a hexacordinated heme iron pocket similar to other pentacoordinated globin proteins. CYGB shares a common phylogenetic ancestry with vertebrate myoglobin from which it diverged by duplication before the appearance of jawed vertebrates. CYGB is ubiquitously expressed in all tissues albeit at varying levels and has been characterised as a respiratory protein in connective tissues. Interestingly, hypoxia induces CYGB expression, suggesting that it may play a role in the maintenance of oxygen homeostasis within the cell. The objective of this study is to identify the regulatory elements that control human CYGB gene expression and to unravel the underlying molecular mechanisms by which hypoxia regulates its expression. In this study, 5' unidirectional deletion constructs demonstrated that the proximal promoter region of human CYGB gene was located between -1113 to -10 relative to the translation start site. Site-directed mutagenesis showed that mutation of the c-Ets-1 motif at -1008 and Sp1 motifs at -400, -230 and -210 remarkably decreased the promoter activities. Our results also revealed the presence of a transcriptional repressor (ZNF202) motif at position -50. Gel shift assays confirmed the binding of DNA-nuclear proteins to these motifs. Taken together, these results indicate that CYGB gene is activated by c-Ets-1 and Sp1 and down-regulated by a transcriptional repressor (ZNF202). When cells were subjected to hypoxia (1% oxygen), the endogenous expression of CYGB was up-regulated to a maximum of 1.73 fold in BEAS-2B cells at 3h (pDOI: 10.5353/th_b3860145 Subjects: Globin - Synthesis - Regulation Globin genes - Expression Oxidative stress


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Product Details
  • ISBN-13: 9781374677074
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 224
  • Weight: 812 gr
  • ISBN-10: 1374677078
  • Publisher Date: 27 Jan 2017
  • Binding: Hardback
  • Language: English
  • Spine Width: 14 mm
  • Width: 216 mm

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