The Role of Dendritic Cells in Epstein-Barr Virus Infection
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The Role of Dendritic Cells in Epstein-Barr Virus Infection

The Role of Dendritic Cells in Epstein-Barr Virus Infection


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This dissertation, "The Role of Dendritic Cells in Epstein-Barr Virus Infection" by Yichen, Chen, 陳以晨, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled The Role of Dendritic Cells in Epstein-Barr Virus Infection Submitted by Chen Yi Chen for the degree of Doctor of Philosophy at the University of Hong Kong In May 2006 Dendritic cells (DCs) are professional antigen-presenting cells and work as the sentinels against infection. Epstein-Barr virus (EBV) is a ubiquitous human B-lymphotropic herpesvirus that is present in more than 95% of the world adults regardless of geographical location. EBV is generally spread among young children, and has been implicated in association with a wide variety of diseases. The role of DCs in the pathogenesis of EBV infection, however, is not clearly understood. By in-situ hybridization, polymerase chain reaction (PCR), reverse transcription coupled-PCR (RT-PCR), western blotting and quantitative PCR analysis, it was demonstrated that both myeloid and plasmacytoid DCs could be latently infected by EBV. In addition, EBV DNA could also be detected in the autologous B cells after co-culturing with EBV-exposed DCs. Since these B cells had no detectable EBV DNA immediately after primary isolation, the results suggested that either DNA or the viral particle might be transmitted from DCs to B cells. Exposure to EBV did not affect the function or survival of myeloid DCs. However, maturation of plasmacytoid DCs induced by CpG-oligonucleotides (CpG-ODN) and their ability to secrete alpha-interferon (IFN-α), a key factor involved in antiviral mechanism of the innate immune system, was impaired by EBV infection. Moreover, - 1 - the maturation and the functions of myeloid DCs could be indirectly affected by EBV through plasmacytoid DCs. When MDC were co-cultured with EBV infected plasmacytoid DCs, its ability to produce inflammatory cytokines such as IL-12 and TNF-alpha were reduced, which may result in a dysregulated anti-viral defense mechanism. Taken together, both myeloid and plasmacytoid DCs are the targets of EBV and can present EBV genome to autologous lymphocytes. On the other hand, EBV can directly affect plasmacytoid DCs maturation and functions, which in turn could impair the maturation of myeloid DC in vicinity. Data presented in the current study reveal possible pathways by which EBV could escape immune surveillance through its suppressive effects on DCs functions. (word count: 316) - 2 - DOI: 10.5353/th_b3747339 Subjects: Dendritic cells Epstein-Barr virus Epstein-Barr virus diseases - Immunological aspects


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Product Details
  • ISBN-13: 9781374673663
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 236
  • Weight: 558 gr
  • ISBN-10: 1374673668
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 13 mm
  • Width: 216 mm


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