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Home > Medicine & Health Science textbooks > Surgery > Characterization of Phospholipid Transfer Protein (Pltp) in Hepatocellular Carcinoma
Characterization of Phospholipid Transfer Protein (Pltp) in Hepatocellular Carcinoma

Characterization of Phospholipid Transfer Protein (Pltp) in Hepatocellular Carcinoma


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This dissertation, "Characterization of Phospholipid Transfer Protein (PLTP) in Hepatocellular Carcinoma" by 盧家健, Ka-kin, Lo, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled as Characterization of Phospholipid Transfer Protein (PLTP) in Hepatocellular Carcinoma Submitted by Lo Ka Kin for the degree of Master of Philosophy at The University of Hong Kong in August 2007 Phospholipid transfer protein (PTLP) has a well-known function on transferring phospholipid between the lipoproteins. It is also responsible to regulate cholesterol level and modification of high density lipoprotein. Much research related to PLTP is focused on atherosclerosis and lipoprotein metabolism, but studies on the relationship between the PLTP and cancer are limited. In our recent cDNA microarray study, we observed that PLTP mRNA was up-regulated in hepatocellular carcinoma (HCC), comparing to the non-tumor liver tissues and normal liver tissues. The location of PLTP gene, 20q chromosome, was also frequently amplified in HCC. In addition, it has been suggested that cholesterol may play a promotion role in prostate cancer progression by influencing the signal transduction, including the signalling of epithelial growth factor receptor (EGFR). Moreover, PLTP mRNA was found to be over-expressed in the oviduct during pregnancy. This suggested that PLTP was important in trophoblast formation by enhancing the invasiveness and angiogenesis, which are crucial features of cancer metastasis. Therefore, we hypothesize that PLTP should play an important role in HCC. To consolidate the role of PLTP in HCC, we examined PLTP mRNA expression in HCC by RT-qPCR in an independent sample set. By Western Blot and immunohistochemistry, the PLTP protein levels were compared and the localization was revealed in the parallel patient samples. ELISA was also performed to measure the serum PLTP concentration. Moreover, Full length PLTP was over-expressed into HCC cell lines, and a series of in vitro function assays and in vivo tumourigenicity test were done for examining the functional role of PLTP in HCC. By immunohistochemistry, PLTP protein staining was observed in the tumor cytoplasm and cell membrane, and the PLTP protein signal of the HCCs were higher than their paralleled non-tumor liver tissues (73%, 55/75). Up-regulation of PLTP in HCCs was associated with advanced tumor stage (P=0.007). These findings were similar to the RT-qPCR that higher PLTP mRNA level was found in HCCs with advanced tumor stage. The Western Blot analysis showed that PLTP protein level was higher in the HCCs than in the adjacent non-tumor liver tissue. In addition, ELSIA showed that the serum PLTP level was higher in HCC patient than in healthy individual. For the in vitro functional studies, an up-regulation of PLTP could increase the adhesion efficiency (PUp-regulation of PLTP in HCC is associated with advanced tumor stage. PLTP expression enhances adhesion, migration, invasion and anchorage- independent growth of HCC cells and promotes the tumor growth in nude mice. The current study demonstrated that PLTP has important functional role in the progression and can serve as a potential therapeutic target. DOI: 10.5353/th_b3955720 Subjects: Phospholipids Liver - Can


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Product Details
  • ISBN-13: 9781374672949
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 130
  • Weight: 318 gr
  • ISBN-10: 1374672947
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 7 mm
  • Width: 216 mm


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