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Home > Medicine & Health Science textbooks > Medicine: general issues > Longitudinal Study of White Matter Fractional Anisotropy in Childhood Medulloblastoma Survivors by Diffusion Tensor MR Imaging
Longitudinal Study of White Matter Fractional Anisotropy in Childhood Medulloblastoma Survivors by Diffusion Tensor MR Imaging

Longitudinal Study of White Matter Fractional Anisotropy in Childhood Medulloblastoma Survivors by Diffusion Tensor MR Imaging


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About the Book

This dissertation, "Longitudinal Study of White Matter Fractional Anisotropy in Childhood Medulloblastoma Survivors by Diffusion Tensor MR Imaging" by Nga-yee, Ho, 何雅儀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract With recent advances in medical treatment, the survival rates for children with medulloblastoma have improved. Whilst cranial irradiation has demonstrated deleterious effects on later cognitive function, early detection of treatment-induced brain injury by sensitive indicator is of vital importance for assessment of timing and application of neurotoxic treatment, and subsequent monitoring of late neurocognitive seguelae. This study aimed at examining the longitudinal trend of white matter fractional anisotropy (FA) and the percentage change in FA (∆FA) as compared with the age-matched normal controls over time since cranial spinal irradiation (CSI) for childhood medulloblastoma survivors by diffusion tensor MR imaging (DTI). A retrospective cohort study was conducted on 22 children medulloblastoma survivors who were of age ≦ 18 at diagnosis and had undergone tumour resection and CSI. 81 age-matched normal control subjects were recruited to provide reference values of FA for comparison with the medulloblastoma patients. Random intercept models were used to determine the impact of age at CSI, age at DTI, gender, CSI dosage, time since CSI and DTI protocol on FA. Significant increases of 0.00418 in FA (p=0.0013) and 1.0007% in ∆FA (p=0.0061) were found for a one year increase in age at CSI. The FA of patients was significantly lower than that of the age-matched normal controls before 16.6y while vice versa afterward (p=0.0064). The rate of change in FA for patients was significantly faster than that of the controls as age at DTI increased (p=0.0064). Gender, CSI dosage and time since CSI had no statistically significant effect on predicting the longitudinal trend of FA nor ∆FA. i In conclusion, the white matter FA of medulloblastoma survivors was significantly lower than that of the age-matched normal controls. In addition, age at CSI was found to be a significant factor for predicting the longitudinal trend of white matter FA and loss of anisotropy in children treated with cranial spinal irradiation for medulloblastoma. ii DOI: 10.5353/th_b3984904 Subjects: Medulloblastoma - Diagnosis Brain - Diseases - Magnetic resonance imaging Children - Diseases - Longitudinal studies


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Product Details
  • ISBN-13: 9781374663343
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 88
  • Weight: 227 gr
  • ISBN-10: 1374663344
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 5 mm
  • Width: 216 mm


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Longitudinal Study of White Matter Fractional Anisotropy in Childhood Medulloblastoma Survivors by Diffusion Tensor MR Imaging
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