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Modulation of Intestinal Epithelial Cell-Mediated Defence Responses by Metabolic Products of Lactobacillus Rhamnosus Gg and Escherichia Coli Nissle 1917

Modulation of Intestinal Epithelial Cell-Mediated Defence Responses by Metabolic Products of Lactobacillus Rhamnosus Gg and Escherichia Coli Nissle 1917


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About the Book

This dissertation, "Modulation of Intestinal Epithelial Cell-mediated Defence Responses by Metabolic Products of Lactobacillus Rhamnosus GG and Escherichia Coli Nissle 1917" by Zhijian, Chen, 陈智健, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Probiotics are defined as live microorganisms that confer beneficial effects to health when administered in a sufficient amount. In previous studies about the beneficial effects of probiotic bacteria to health, particularly in the fields of intestinal mucosa defence responses, specific probiotics, in a strain-dependent manner, show some potential to reinforce the integrity of intestinal epithelium and/or regulate some immune components. However, the mechanisms involved in the interactions between probiotics or bioactive components of probiotics with the intestinal epithelium are still not yet clearly defined or systematically studied. Among all possible routes of modulation by probiotics of intestinal epithelial cell-mediated defence responses, modulations of mucin and trefoil factor expression as well as the cytokine profiles are important components of the innate and adaptive mucosal immune responses of the intestinal epithelial cells and are considered to play important role in the intestinal defence responses against pathogenic bacteria. This thesis examined and characterized the in vitro modulation effects by metabolic products of two commonly studied probiotics bacterial strains, Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN), on the intestinal epithelial cell-mediated defence responses. It was found that the metabolic products of EcN decreased the transcriptional levels of secretory mucins MUC5AC, MUC5B and MUC2 while LGG metabolic products only down-regulated that of MUC5AC. In partial agreement with the reduction of mucin gene expression levels, intracellular MUC5B and MUC2 mucin expression was reduced by EcN metabolic products and MUC5AC and MUC2 by the metabolic products of LGG. In contrast, the extracellular MUC5AC and MUC2 mucin expression tended to increase upon the effects of both LGG and EcN metabolic products, which might result from accumulative effects of the modulation on extracellular mucin secretion during the time of treatment or the differential responsiveness of cellular mucin gene and protein expression upon stimulation. The expression of trefoil factor 3 in both gene and protein levels upon the effects of EcN metabolic products while those of LGG enhanced the transcriptional but not protein level. As for the modulation of cytokine profiles, LGG metabolic products mainly influence the secretion of anti-inflammatory cytokines such as IL-4, IL-5 and IL-10 in a moderate manner while EcN metabolic products exerted broad pro-inflammatory potential to the intestinal epithelial cells by inducing the secretion of pro-inflammatory cytokines such as IL-8, MCP-1, TGF-α, TNF-α and GM-CSF, which indicated that the metabolic products of LGG and EcN might initiate differential signaling pathway to influence the intestinal epithelial adaptive immune responses. To conclude, the present research provides evidence to substantiate that LGG and EcN display differential modulation mechanisms of the intestinal epithelial cell-mediated defence responses that involve intestinal-cell mediated mucin and trefoil factor secretion as well as pro- and anti-inflammatory cytokine expression. DOI: 10.5353/th_b4979967 Subjects: Intestines - Infections Epithelial cells Intestinal mucosa Lactobacillus Escherichia coli


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Product Details
  • ISBN-13: 9781361308769
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 170
  • Weight: 408 gr
  • ISBN-10: 1361308761
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 9 mm
  • Width: 216 mm

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Modulation of Intestinal Epithelial Cell-Mediated Defence Responses by Metabolic Products of Lactobacillus Rhamnosus Gg and Escherichia Coli Nissle 1917
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