Buy The Role of Secretin in Appetite Control - Bookswagon
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > History and Archaeology > History > The Role of Secretin in Appetite Control
The Role of Secretin in Appetite Control

The Role of Secretin in Appetite Control


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

This dissertation, "The Role of Secretin in Appetite Control" by Yuen-yee, Cheng, 鄭婉兒, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Multiple gut hormones are involved in the regulation of food intake. Secretin (SCT), a classical gut hormone, is released into the circulation from the duodenal S-cells when acidic chyme enters the duodenum and performs the major functions of delaying gastric emptying, stimulating fluid secretion from pancreas and liver to optimize the digestion process. In recent years, SCT and its receptor (SCTR) have been identified in discrete nuclei of the hypothalamus, including the paraventricular nucleus (PVN) and the arcuate nucleus (Arc). The occurrence of SCT and SCTR in the brain regions that are engaged in regulating body energy homeostasis and the release pattern of SCT after meals support a functional role of SCT in appetite control. In this study, the effect of SCT on feeding behavior was investigated using wild-type (wt), SCT?/?, and SCT receptor-deficient (SCTR?/?) mice. We found that both central and peripheral administration of SCT could reduce food intake in wt but not in SCTR?/?mice. SCT induce Fos expression in the PVN and Arc, suggesting the activation of hypothalamic feeding centers by this peptide. Consistent with this notion, SCT was found to increase proopiomelanocortin (POMC), but reduce agouti-related protein (AgRP) transcripts in the Arc, and augment thyrotropin-releasing hormone (TRH) and melanocortin-4 receptor (MC4R) mRNA expression in the PVN. In addition, pretreatment with SHU9119, an antagonist for MC4R, abolished the anorexia induced by SCT, suggesting that SCT may inhibit food intake via a melanocortin-dependent pathway. Gut hormones signals the brain to modulate the feeding behavior via the vagal afferent nerve, bloodstream or both. Here we showed that peripheral SCT-induced anorexia was attenuated in mice with subdiaphragmatic vagotomy, capsaicin treatment and bilateral midbrain transections. In summary, our data identify peripheral SCT as an anorectic peptide exerting its action via the melanocortin system and the vagal afferent contributes a major route in mediating the inhibitory effect of peripheral SCT on food intake. The present findings advance our understanding of the role of gut hormones in the regulation of appetite. DOI: 10.5353/th_b4775295 Subjects: Secretin Appetite - Physiological aspects


Best Sellers


Product Details
  • ISBN-13: 9781361290323
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 196
  • Weight: 748 gr
  • ISBN-10: 1361290323
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Language: English
  • Spine Width: 13 mm
  • Width: 216 mm

Related Categories

Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
The Role of Secretin in Appetite Control
Open Dissertation Press -
The Role of Secretin in Appetite Control
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

The Role of Secretin in Appetite Control

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!