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Synaptic Modulation by 5-Hydroxytryptamine in the Rat Hypothalamic Paraventricular Nucleus

Synaptic Modulation by 5-Hydroxytryptamine in the Rat Hypothalamic Paraventricular Nucleus


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This dissertation, "Synaptic Modulation by 5-hydroxytryptamine in the Rat Hypothalamic Paraventricular Nucleus" by Sze-ngar, Sara, Ho, 何思雅, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled SYNAPTIC MODULATION BY 5-HYDROXYTRYPTAMINE IN THE RAT HYPOTHALAMIC PARAVENTRICULAR NUCLEUS Submitted by HO Sze Ngar Sara for the Degree of Master of Philosophy at The University of Hong Kong in August 2005 The hypothalamic paraventricular nucleus (PVN) is an integrative site for autonomic, neuroendocrine, and behavioral responses. It is innervated by various fibers, including GABAergic, glutamatergic and serotonergic inputs. PVN magnocellular neurons synthesize and secrete two neurohypophysial hormones, vasopressin and oxytocin, to the posterior pituitary via axonal transport in response to different stimuli. Recent evidence that 5-hydroxytryptamine (5-HT) increases the release and gene expression of these two peptides suggests 5-HT can excite the PVN magnocellular neurons. The underlying mechanisms for such excitatory action remain to be established. In this study, the pre- and postsynaptic effects of 5-HT in the electrophysiologically identified PVN magnocellular neurons were examined using whole-cell patch clamp. 5-HT (0.01 - 100 μM) reduced the miniature inhibitory postsynaptic currents (mIPSCs) frequency in a dose-dependent manner (IC = 0.89 50 μM; maximum inhibition = 63.5%). This inhibition was mimicked by 5-HT 1B agonist CP93129, and reversed in the presence of 5-HT antagonists 1B Cyanopindolol and SB224289, and G protein blocker N-ethylmaleimide. At high concentrations of 5-HT (10 μM or above), the mIPSCs amplitude was significantly decreased. Besides, 5-HT (1 - 100 μM) induced a biphasic effect on miniature excitatory postsynaptic currents (mEPSCs) frequency, comprising a transient inhibition followed by a delayed concentration-dependent excitation (onset latency ≈ 5 min). The prominent facilitation was mimicked by 5-HT agonist DOI and 2A/2C abolished in the presence of 5-HT antagonist RS102221. Preincubation with 2C adenylate cyclase inhibitor SQ22536 partially blocked the presynaptic excitation. Although the receptor subtypes involved in mEPSCs frequency suppression were uncertain, 5-HT antagonist WAY100635 and 5-HT antagonist SB224289 1A 1B seemed effective to prevent the presynaptic inhibition in some cells. At postsynaptic level, 5-HT (50 μM) produced a minuscule inward current (5.9 0.8 pA, n = 12) in 48% (12 out of 25) of cells, which was attenuated when 5-HT antagonist GR113808 or 5-HT antagonist SB269970 was added. 5-HT (50 μM) also weakly depolarized PVN magnocellular neurons (3.7 0.2 mV, n = 4), and this depolarization persisted in the presence of sodium-channel blocker tetrodotoxin in 33.4% (4 out of 12) of cells (4.5 0.6 mV, n = 4). Present findings indicate that 5-HT directly increases the excitability of the PVN magnocellular neurons via multiple receptor subtypes and different synaptic mechanisms. This may help understanding the regulation of 5-HT-induced hormone release and feeding behavior in the PVN. DOI: 10.5353/th_b3194341 Subjects: Hypothalamus - Physiology Serotonin Neurons Rats - Physiology


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Product Details
  • ISBN-13: 9781361235645
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 186
  • Weight: 445 gr
  • ISBN-10: 1361235640
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 10 mm
  • Width: 216 mm


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