Buy Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pathology > Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis
Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis

Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

This dissertation, "Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis" by Oi-lin, Irene, Ng, 呂愛蓮, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis Submitted by Irene Oi-lin NG For the degree of Doctor of Philosophy at the University of Hong Kong in September 2005 Hepatocellular carcinoma (HCC) is one of the commonest malignancies worldwide and also in Southeast Asia and Hong Kong. Similar to other cancers, hepatocarcinogenesis is of a multistep process. However, systematic analysis using a genetic or molecular approach to accurately delineate the different steps/stages of HCC development is scarce. The aim of this study was to systematically evaluate the allelic alterations in the multi- steps in hepatocarcinogenesis including chronic hepatitis/cirrhosis, dysplastic nodules, primary and metastatic HCCs. In order to delineate tumor progression pathologically, a large cohort of 655 patients with resected primary HCC was studied. Tumor progression, as reflected by growth of tumor size, was associated with a more aggressive behavior with more frequent venous invasion and tumor microsatellite formation, and advanced tumor stage. To delineate the frequency of allelic losses in chronic hepatitis and cirrhosis, genome- wide allelotyping was performed, by comparing them with the corresponding normal DNA. Loss of heterozygosity (LOH) in cirrhotic/chronic hepatitis livers was uncommon, with overall fractional allelic loss (FAL) index of 0.005. In contrast, LOH was a common occurrence in the corresponding predominantly hepatitis B virus (HBV)-associated HCCs, with 70.6% exhibiting LOH at >=1 loci and an overall FAL index of 0.169 0.002. The development of dysplastic nodule (DN) has been the subject of study with regard to its role in hepatocarcinogenesis. All the 17 DNs from 13 patients who underwent either surgical resection or liver transplantation showed LOH at one or more loci on the chromosomes tested. Importantly, the FAL of the high-grade DNs (0.34 0.20) was significantly higher than that of the low-grade DNs (0.16 0.07) and was close to that of HCC, showing that high-grade DNs are genetically and thus behavior-wise close to HCC. The FAL index was determined in 74 HCC nodules (mean S.D., 0.39 0.23). The molecular relationship between multiple tumor nodules (n = 25) in HCC within individual patients (n = 11) was also determined with both LOH assay and comparative genomic hybridization (CGH). The results indicated that in 36% of patients, the multiple HCCs had different clonalities, hence of multicentric origin, whereas in the remaining 64% patients, the multiple HCCs had similar clonal relationship, hence of intrahepatic metastasis (IM). Assessment of DNA alterations allowed precise determination of the clonality of multiple HCCs within one patient. Also, a cut-off value of 30% of discrepancy of LOH patterns between the nodules was found to distinguish IM and multicentric occurrence. Consistently, those multinodular HCCs with Overall, hepatocarci


Best Sellers


Product Details
  • ISBN-13: 9781361123249
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 218
  • Weight: 517 gr
  • ISBN-10: 1361123249
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 12 mm
  • Width: 216 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis
Open Dissertation Press -
Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Allelic and Molecular Changes in Multistep Process of Hepatocarcinogenesis

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!