Buy Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas
close menu
Bookswagon
search
My Account
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Gynaecology and obstetrics > Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas
Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas

Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

This dissertation, "Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas" by Yue, Wang, 王悦, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas Submitted by Wang Yue for the degree of Doctor of Philosophy at The University of Hong Kong in June 2005 Recently, mitochondrial DNA (mtDNA) mutations and genetic instability were frequently detected in a number of human cancers. However, the occurrence of mtDNA alterations in endometrial carcinomas is still unknown. This study aims to identify the frequency and characteristics of mtDNA alterations in endometrial carcinomas. To identify somatic mtDNA mutations, DNA sequencing was performed on the mutational hotspot region of mtDNA in endometrial carcinomas and matched normal controls. The frequency of the T→C polymorphism at nucleotide position (np) 16189 was also determined in endometrial carcinomas and compared with the frequencies detected in cervical, ovarian and breast cancers as well as in the general population. The mitochondrial microsatellite instability (mtMSI) in the above four types of cancers was also evaluated. The nuclear MSI (nMSI), the germline mutations of the core genes of the mismatch repair system and methylation status of hMLH1, APC INK4A and p16, were also studied in endometrial carcinomas. 1The copy number of mtDNA in endometrial cancer cells procured by laser capture microdissection (LCM) was determined by real-time quantitative PCR and compared with normal endometrial cells obtained from the same patient. Moreover, by using LCM, mtDNA sequence alterations were analyzed on different loci from the same lesion of a subset of endometrial carcinomas. Finally, the mtDNA copy number and the expression level of mtDNA-encoded genes on estrogen-sensitive RL95-2 cells were quantified by real time PCR, RT-PCR and Western blotting assays. A remarkably high frequency (56%, 28/50) of somatic mtDNA mutations in endometrial carcinomas was observed. MtMSI constituted the majority (89%, 25/28) of the somatic changes detected. And the frequency of mtMSI was significantly higher than the other three types of cancers including cervical, ovarian and breast cancers (χ, P


Best Sellers


Product Details
  • ISBN-13: 9781361111239
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 256
  • Weight: 599 gr
  • ISBN-10: 1361111232
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 14 mm
  • Width: 216 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas
Open Dissertation Press -
Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Molecular Analysis of Mitochondrial DNA Alterations in Endometrial Carcinomas

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    Your IP: 216.73.216.150 IN