Buy Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Dentistry > Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla
Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla

Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

This dissertation, "Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla" by Laddawun, Sununliganon, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Inadequate bone volume on the posterior maxilla limits dental implant rehabilitation. Maxillary sinus grafting is often indicated to increase the bone volume in this region. Bone marrow aspirate concentrate (BMAC), a cellular-based therapy, has been recently introduced as a chair-side procedure. The overall aim of this thesis is to develop a single-visit clinical stem cell therapy for maxillary sinus bone grafting in atrophic maxilla using bone marrow derived MSC from BMAC. The study aimed to evaluate the quantity of nucleated cells, MSCs and their differentiation capacity in the bone marrow aspirate and BMAC in rabbits and humans. The bone regeneration and healing of maxillary sinus graft using different grafting materials in combination with BMAC were evaluated in rabbits and humans. Materials and methods involved an in vitro laboratory experiment, an in vivo animal experiment and a preliminary human clinical trial. The bone marrow aspirates from the rabbits and humans were submitted for the quantitative and qualitative analyses of the nucleated cells and the differentiation capacity of the MSCs before and after concentration. The rabbit maxillary sinus model was used to test the different grafting materials. 24 rabbits with 48 sinuses were randomized into 4 groups: sham control, autogenous bone, bovine bone mineral (BBM) and BBM+BMAC. The rabbits were sacrificed at 2, 4 or 8 weeks and the sinuses were analyzed by histological examination and micro-CT scan. In the human clinical trial, the patients were divided into 2 groups basing on their grafting need for dental implant rehabilitation. On bilateral sinus grafting (study 1), it was a split mouth design comparing BBM and BBM+BMAC and on unilateral sinus grafting (study 2), it was a randomized controlled design comparing BBM+BMAC and autogenous bone. The bone regeneration capacity was assessed histologically by trephine biopsy and cone beam CT scans for graft volume and graft height. Results of the in vitro study confirmed that the quantity of nucleated cells and colony forming unit-fibroblasts after concentration have increased substantially when compared with before concentration in rabbits at a factor of 1.84 and 3.76, respectively, and in humans at a factor of 4.43 and 106.88, respectively. The BMAC could retain their in vitro multi-differentiation capability of osteogenic, chondrogenic and adipogenic lineage. In the in vivo rabbit study, bone regeneration and satisfactory healing of maxillary sinus grafts using either autogenous bone, BBM or BBM+BMAC was confirmed. The quantity of new bone increased and demonstrated interconnection with no sign of inflammatory changes. BBM or BBM+BMAC retained more graft volume rather autogenous bone. In the preliminary clinical study, bone-aspirating technique did not produce any morbidity and higher patients' satisfaction when compared with hip harvesting. On evaluation of bone healing after maxillary sinus grafting, both BBM and BBM+BMAC underwent similar trend of slow graft reduction. The BMAC+BBM could retain greater volume than autogenous bone. In conclusion, a single-visit stem cell therapy for maxillary bone grafting in atrophic maxilla using BMAC+BBM have been developed based on in vitro laboratory and in vivo rabbit experiments and substantiated by a preliminary clinical trial. DOI: 10.5353/th_b5089951 Subjects: Maxillary sinusBone-grafting


Best Sellers


Product Details
  • ISBN-13: 9781361039212
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • Weight: 721 gr
  • ISBN-10: 1361039213
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Spine Width: 13 mm
  • Width: 216 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla
Open Dissertation Press -
Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Stem Cell Approach for Maxillary Sinus Grafting in Atrophic Maxilla

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!