Investigating the Role of the Forkhead Box Transcription Factor Foxm1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells
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Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Investigating the Role of the Forkhead Box Transcription Factor Foxm1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells
Investigating the Role of the Forkhead Box Transcription Factor Foxm1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells

Investigating the Role of the Forkhead Box Transcription Factor Foxm1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells


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About the Book

This dissertation, "Investigating the Role of the Forkhead Box Transcription Factor FOXM1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells" by Man-hong, Leung, 梁文康, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: (MnSOD or SOD2) and catalase (CAT), which defend against reactive oxygen species. A number of DNA repair genes such asBRCA1 interacting protein C-terminal helicase 1 (BRIP1) and RAD51 recombinase (RAD51) have recently been shown to be the transcriptional targets of FOXM1. It is hypothesized that FOXM1 is a critical regulator for maintaining genome stability in hESCs. In this study, FOXM1 was found to be expressed at high levels in the hESC cell line VAL-3.Hydrogen peroxide, as a model oxidant and potent DNA damaging agent, was used to study the response of hESCs to oxidative stress and DNA damage. Cell viability and morphology of hESCs were assessed after exposure to hydrogen peroxide. Knockdown of FOXM1 using specific siRNAs reduced cell proliferation rate but did not affect pluripotency of VAL-3 hESCs. Moreover, loss of FOXM1 expression down-regulated the expression of antioxidant enzyme CAT and FOXM1-depleted VAL-3 cells became sensitized to oxidative stress. Interestingly, comparison of mRNA and protein levels suggested that the FOXM1 protein was stabilized under oxidative stress. Immunostaining of FOXM1 showed that oxidative stress could induce transient nuclear translocation of FOXM1 in hESCs. These findings suggested that FOXM1 may play important roles in protecting hESCs against oxidative stress and DNA damage by the stabilization and increased nuclear translocation of FOXM1 to control the expression of antioxidant enzymes. The underlying mechanisms on how FOXM1 is regulated in response to oxidative stress in hESCs require further investigation. DOI: 10.5353/th_b5388006 Subjects: Embryonic stem cells Transcription factors Oxidative stress DNA damage


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Product Details
  • ISBN-13: 9781361024119
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 120
  • Weight: 295 gr
  • ISBN-10: 1361024119
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 6 mm
  • Width: 216 mm


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Investigating the Role of the Forkhead Box Transcription Factor Foxm1 Against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells
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