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Home > Medicine & Health Science textbooks > Pre-clinical medicine: basic sciences > Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells
Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells

Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells


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About the Book

This dissertation, "Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells" by Jiaozi, He, 何骄子, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells Submitted by Jiaozi, HE for the degree of Master of Philosophy at The University of Hong Kong in Aug 2015 Recent advances in directed cardiac differentiation methodologies provide great promises in stem cell transplantation therapy for treating incurable cardiovascular diseases. However, immune rejection remains to be a major obstacle to the success of stem cells-based therapies. Dendritic cells (DCs) dictate pivotal roles in the establishment of alloantigen specific immunity. Here we sought to examine if human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs) exert any immunomodulatory effects on DC function. We differentiated human ESCs into highly purified VCMs and cocultured with human monocyte-derived DCs during lipopolysaccharide (LPS)- induced maturation. Our finding indicated the DCs cocultured with hESC- VCMs during LPS activation ( DCs) displayed distinct phenotypes of VCM/LPS 'semi-mature' DCs with high expression of MHC II and costimulatory molecule CD86 but lower levels of CD80, CD40, PD-L1, and PD-L2. ICOS-L expression on DCs was higher than control DCs. The ability to secrete pro- VCM/LPS inflammatory cytokine IL-12 was reduced in DCs while levels of TNF-α, VCM/LPS IL-6, IL-1 secretions were similar to those of DCs. A higher level of IL-10 LPS production by DCs was observed. DCs exhibited an abolished VCM/LPS VCM/LPS ability to stimulate allogeneic CD4 T cell proliferation and the activated T cells were hyporesponsive to further stimulation. Despite no increase of indoleamine 2,3-dioxygenase (IDO) and TGF- secretion by VCM/LPSDCs, VCM/LPSDCs + + + acquired an enhanced ability to promote CD4 CD25 Foxp3 regulatory T cells (Tregs) differentiation. In sum, our data demonstrated that hESC-VCMs exhibited immune privilege property by impairing DC ability to trigger effective T cell response and hence tolerance may be achieved with minimal immune suppressive regimen after allogeneic transplantation. Subjects: Heart cells Stem cells Dendritic cells


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Product Details
  • ISBN-13: 9781361012536
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 136
  • Weight: 331 gr
  • ISBN-10: 1361012536
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Spine Width: 7 mm
  • Width: 216 mm


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Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Exhibits Immunosuppressive Effects Toward Dendritic Cells
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