Buy Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Science, Technology & Agriculture > Energy technology and engineering > Electrical engineering > Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles
Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles

Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

This dissertation, "Development of Biodetection Platform With Magnetoresistive Sensors and Magnetic Nanopartcles" by Li, Kirsten, Li, 李丽, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Compared with traditional radioimmunoassay and fluoroimmunoassay for early diseases detection, the magnetic immunoassay utilizing magnetic nanoparticles as bio-labels and magnetic signal sensors as detectors has remarkable advantages because most biological samples exhibit no magnetic background and highly sensitive measurements can be performed. This thesis presents the development of biodetection platform taking advantage of the physical-and chemical-stability, low-toxicity, and environmentally-safety of magnetic iron oxide nanoparticles (IONPs) and the high-sensitivity, low-cost, and portable capabilities of magnetoresistive (MR) sensors. The first part explained why a magnetic biodetection platform is desirable, and what advantages it possesses. Then the magnetism of IONPs utilized in this detection system was introduced, followed by the introduction of main synthesis methods to obtain the desirable IONPs. The working principle of MR sensor was explained, and the recent advances about the biodetection platforms with various magnetoresistive sensors and magnetic IONPs labeling was reviewed. A brief summary of new contributions reported in this thesis was summarized. Then the establishment of home-made measurement setups for the characterization of MR sensor was described. The MR loops of MR sensors can be obtained with the instrument using two-point probe measurement, four-point probe measurement, or Wheatstone bridge measurement. The single MTJ sensor, MTJs array sensor, and the GMR spin valve sensor in Wheatstone bridge were characterized here. The magnetic IONPs were prepared through co-precipitation method and thermal decomposition method, and then surface-functionalized using citric acid and fatty acids to acquire carboxyl groups for the binding ability with biomolecules. The physical and chemical properties, sterilizing-treatment tolerability and biocompatibility of nanoparticles were studied. Furthermore, two new synthesis methods were developed to obtain novel magnetic gold/iron oxide nanocomposites for their potential use as magnetic bio-labels. A magnetic detection platform was built, and the detection of 10-nm superparamagnetic IONPs with MR sensor was first realized here. The output signal of the giant magnetoresistive (GMR) sensor in Wheatstone bridge exhibited log-linear function of the concentration of IONPs, making our sensing system suitable for use when ultra-small bio-labels are needed. The biodetection platform with MR sensor and IONPs was successfully developed and applied for the detection of antigen biomolecules. The feasibility of magnetic biodetection system, based on magnetic tunneling junction (MTJ) sensors and carboxyl-group functionalized IONPs, to detect AFP antigens (liver cancer biomarker) and p24 antigens (HIV biomarker) was demonstrated here for the first time. By taking advantages of its high sensitivity, low power consumption, low cost, and feasibility to be miniaturized, the development of magnetoresistive biodetection platform will bring revolutionary impact on the biodetection techniques for clinical early diseases diagnosis. DOI: 10.5353/th_b5089979 Subjects: Biosensors Nanoparticles - Magnetic properties Magnetoresistance


Best Sellers


Product Details
  • ISBN-13: 9781361000045
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 180
  • Weight: 708 gr
  • ISBN-10: 136100004X
  • Publisher Date: 26 Jan 2017
  • Binding: Hardback
  • Language: English
  • Spine Width: 11 mm
  • Width: 216 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles
Open Dissertation Press -
Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Development of Biodetection Platform with Magnetoresistive Sensors and Magnetic Nanopartcles

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!