Buy Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Mathematics and Science Textbooks > Biology, life sciences > Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer
Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer

Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

Blocking the function of CTLA-4, a receptor on T cells that negatively regulates T cell responses, has led to tumor eradication in preclinical mouse models and patients. This treatment is more effective when combined with therapies that increase antigen presentation such as GM-CSF-secreting, irradiated tumor vaccines. Here we explore this synergy in the treatment of mouse TRAMP C2 prostate tumors, using anti-CTLA-4 monoclonal antibodies together with an irradiated tumor vaccine consisting of TRAMP C2 secreting GM-CSF (TRAMP-GM). In order to track the T cell response in mice receiving this combination treatment, we have developed a TCR transgenic mouse whose CD8+ T cells recognize the previously identified TRAMP C2 antigen, SPAS-1. Anti-CTLA-4 and TRAMP-GM combination therapy stimulates T cells from these mice (SPASTCs) to proliferate and accumulate in TRAMP-C2 tumors compared to untreated controls. However, the combination therapy does not increase the percentage of SPASTCs producing the effector cytokine IFNgamma. Investigation of the individual components of this therapy reveals that TRAMP-GM drives SPASTCs to proliferate in the lymph node, while anti-CTLA-4 monotherapy mediates the accumulation of SPASTCs within the tumor. We hypothesize that in the TRAMP-C2 system, CTLA-4 blockade mediates increased T cell trafficking to tumors and while the therapy does not increase effector function on a per cell basis, the overall increase in effector T cells within the tumor leads to tumor eradication. We are also investigating clinically relevant therapies that release antigens through the destruction of tumor tissue. These therapies augment antigen presentation and therefore have the potential to synergize with CTLA-4 blockade. For example, we determined the effects of cryoablating an established TRAMP-C2 tumor in combination with anti-CTLA-4 on the growth of a second tumor challenge at a distant site. While growth of the second tumor is unaffected by cryoablation alone, the combination treatment leads to slower tumor growth or rejection. Additionally, secondary tumors from combination treated mice are highly infiltrated by SPAS-1 specific CD8+ T cells. While cryoablation is currently used clinically to treat the targeted tumor nodule, our results suggest that combination therapy with CTLA-4 blockade can induce anti-tumor immunity and rejection of tumor metastases.


Best Sellers


Product Details
  • ISBN-13: 9781244008823
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 336 gr
  • ISBN-10: 1244008826
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 10 mm
  • Width: 189 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer
Proquest, Umi Dissertation Publishing -
Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Enhancement of T Cell Responses Through Ctla-4 Blockade Combination Therapy in a Mouse Model of Prostate Cancer

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!