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Home > Society and Social Sciences > Psychology > Quantitative Magnetic Resonance Imaging of the Macromolecular Proton Pool in Tissue.
Quantitative Magnetic Resonance Imaging of the Macromolecular Proton Pool in Tissue.

Quantitative Magnetic Resonance Imaging of the Macromolecular Proton Pool in Tissue.


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About the Book

Magnetic resonance imaging (MRI) is an important diagnostic imaging modality due to its outstanding soft tissue contrast. While the signal in conventional MR images comes from the hydrogen in free water, the protons in macromolecules, such as those found in myelin and cartilage, also contribute to it. Quantifying the contribution of macromolecules to the MR signal can serve as an early indicator of cartilage degeneration in osteoarthritis and myelin loss in multiple sclerosis. Bound pool fractions (BPF) are a quantitative magnetic resonance (qMR) marker that estimates the proportion of macromolecules exchanging magnetization with water. Novel applications of bound pool fractions in brain and knee imaging are presented in this thesis, demonstrating the benefits of combining BPFs with other qMR techniques. This thesis introduces a new way of imaging cartilage and myelin using bound pool fractions. We show that bound pool fractions correlate with absolute concentrations of macromolecules in cartilage. BPFs are positively correlated with proteoglycan content, and negatively correlated with collagen content in articular cartilage in the knee. We then look at combining bound pool fractions with diffusion MRI as a unique way of imaging and analyzing the level of myelination of different fiber tracts in the brain. We conclude that bound pool fractions complement existing qMR techniques to provide a more complete insight into tissue microstructure.


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Product Details
  • ISBN-13: 9781243663559
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 209 gr
  • ISBN-10: 1243663553
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 6 mm
  • Width: 189 mm


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Quantitative Magnetic Resonance Imaging of the Macromolecular Proton Pool in Tissue.
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Quantitative Magnetic Resonance Imaging of the Macromolecular Proton Pool in Tissue.
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