Development of Vsv-Based Sars Vaccine Vectors
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Development of Vsv-Based Sars Vaccine Vectors

Development of Vsv-Based Sars Vaccine Vectors


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About the Book

The SARS outbreak was the first infectious disease of the 21st century to grab global attention. Although it was contained by 2003, the chance of a reemergence is probable because meat markets that expose humans to animals carrying the coronavirus that causes SARS (SARS-CoV) are still operational. Because of a this risk and because of the high death rate associated with SARS, a vaccine would be a useful tool for protection in the event of another outbreak. Therefore, we developed a recombinant VSV-based SARS vaccine using the S protein of SARS-CoV as an antigen. We found that in a mouse model a single dose of the vaccine was able to induce a neutralizing antibody response and protect against SARS-CoV infection. Furthermore, we determined that an antibody response was sufficient for this protection. In order to address safety concerns affiliated with a live viral vaccine, we next attenuated our SARS vaccine so that it could only undergo one round of replication. Such a replication-deficient virus would also allow for quick regulatory approval. We found that one dose of this single-cycle vaccine was able to induce a strong neutralizing antibody response that was indicative of protection. We next constructed and characterized various other potential VSV-based SARS vaccines using other SARS-CoV antigens, M, 3a, N and E. Finally, in an effort to minimize potential exposure to SARS-CoV in the laboratory, we developed a VSV-based pseudotype that can substitute for the SARS-CoV in neutralization assays. Unlike, SARS-CoV, this pseudotype does not require biosafety level 3 containment.


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Product Details
  • ISBN-13: 9781243646033
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 240 gr
  • ISBN-10: 1243646039
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 7 mm
  • Width: 189 mm


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