Buy Conditioned Effects of Heroin on Proinflammatory Mediators.
close menu
Bookswagon
search
My Account
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Mathematics and Science Textbooks > Biology, life sciences > Conditioned Effects of Heroin on Proinflammatory Mediators.
Conditioned Effects of Heroin on Proinflammatory Mediators.

Conditioned Effects of Heroin on Proinflammatory Mediators.


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

Heroin administration alters the induction of nitric oxide, a molecule known to play a critical role in immune function, as well as the production of several proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-one beta (IL-1beta). Previous research has shown that these alterations can be conditioned to environmental stimuli that have been associated with drug administration. The investigations presented here deal with the neural mechanisms whereby these drug cues alter the expression and production of certain proinflammatory mediators essential for host defense. The experiments in Chapter 2 demonstrate that the conditioned alterations in proinflammatory mediators induced by exposure to previously heroin-paired stimuli are a true form of associative learning as they are susceptible to both extinction and latent inhibition. Chapter 3 reveals that the basolateral amygdala (BLA), an area of the brain which has been implicated in the formation of stimulus-reward associations within models of drug abuse, is necessary for the expression of the conditioned response. Administration of a combination of the GABA agonists, muscimol and baclofen, directly into the BLA blocked the conditioned suppression of proinflammatory mediators while administration of these same drugs into an adjacent region of the caudate did not alter the response. The experiments outlined in Chapter 4 show that the pharmacological blockade dopamine, D1 receptors in the BLA reverses the conditioned suppression induced by exposure to previously heroin-paired stimuli. The administration of the dopamine D1 antagonist, SCH23390, but not the D2 antagonist, raclopride, resulted in attenuation of the conditioned effect. These studies are important because they are the first to investigate the neural circuitry involved in the conditioned immune alterations produced by exposure to drug cues. Overall, these findings indicate a need to consider the implications of exposure to drug cues on the immune functioning of current and recovering heroin use.


Best Sellers


Product Details
  • ISBN-13: 9781243630742
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 299 gr
  • ISBN-10: 1243630744
  • Publisher Date: 04 Sep 2011
  • Binding: Paperback
  • Spine Width: 9 mm
  • Width: 203 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Conditioned Effects of Heroin on Proinflammatory Mediators.
Proquest, Umi Dissertation Publishing -
Conditioned Effects of Heroin on Proinflammatory Mediators.
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Conditioned Effects of Heroin on Proinflammatory Mediators.

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!