Buy Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Mathematics and Science Textbooks > Biology, life sciences > Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.
Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.

Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

The single-minded (sim) gene in Drosophila melanogaster has long been known to play important roles in specifying the mesectodermal cell fate in the embryonic central nervous system (CNS). Mesectoderm cells differentiate into CNS midline cells by mid-embryogenesis. CNS midline cells contribute both neurons and glia to the developing nervous system, and are a source of both attractive and repulsive axonal guidance cues that combinatorially pattern the bilateral CNS. Removal of sim function leads to the failure of midline cell formation, and concomitantly a lack of instructive signal presentation to pathfinding axons from the lateral CNS. As a result, commissural axon tracts that cross the midline are largely absent and parallel longitudinal axon tracts that flank the midline appear fused as a single connective at the embryonic mid-plane. Due to this patterning defect, sim mutants are late embryonic lethal. In addition to the CNS midline, Sim can also be found in the developing foregut, posterior terminal structures, and a subset of myoblasts, although its roles in these compartments are less well understood. In collaboration with others, we demonstrated functions for sim in developing posterior terminal structures and gonads, patterning the larval cuticle, organizing the adult brain, and in adult behavior and locomotion. Using the MARCM strategy for positively marking sim mutant cell clones, we demonstrated that in contrast to its role in neurogenesis in the CNS mesectoderm, sim functions to pattern axon fascicles in the larval central brain, a region known to be important in the interhemispheric communication and the coordination of leg movement. Using RT-PCR, we showed that the sim locus yields a third, previously unidentified transcript that is the primary isoform used post-embryonically. Genetic dissection of inter- and intragenic regions from the sim locus revealed locations of enhancers that drive expression in the CNS midline, myoblasts, and foregut. Taken together, these results have broadened our understanding of sim, an important regulator of development with complex regulation.


Best Sellers


Product Details
  • ISBN-13: 9781243630285
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 313 gr
  • ISBN-10: 1243630280
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 10 mm
  • Width: 203 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.
Proquest, Umi Dissertation Publishing -
Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Embryonic Regulation and Post-Embryonic Function of the Single-Minded Gene in the Drosophila Central Nervous System.

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!