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Home > Mathematics and Science Textbooks > Biology, life sciences > Genes That Act in Specification of the Vulval Secondary Fate in Caenorhabditis Elegans
Genes That Act in Specification of the Vulval Secondary Fate in Caenorhabditis Elegans

Genes That Act in Specification of the Vulval Secondary Fate in Caenorhabditis Elegans


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LIN-12/Notch signaling is used iteratively throughout development to mediate cell fate specification events. The events activated downstream of LIN-12/Notch signaling are different in every cell type, providing a mechanism by which LIN-12/Notch signaling can result in disparate outcomes in a context dependent manner. C. elegans vulval precursor cell (VPC) fate specification is a model system used to study various aspects of LIN-12/Notch signaling, including the events activated downstream of LIN-12/Notch signaling. In this thesis, I present my work on two aspects of LIN-12/Notch-mediated 2 vulval precursor cell (VPC) fate specification, focusing on events that occur downstream of LIN-12/Notch signaling. Previous work showed that mir-61 is transcriptionally activated by LIN-12 in the 2 VPCs, and suggested that mir-61 and its target, VAV-1, constitute a feedback loop that augments lin-12 activity in specifying the 2 VPC fate. mir-250 is a microRNA likely to be coregulated with mir-61, and here we show that mir-250 and its target CDC-42 also appear to constitute a positive feedback loop on lin-12 activity. While analyzing a deletion mutant of mir-61/250, I serendipitously identified the molecular identity of sel-11, an previously isolated negative regulator of lin-12 activity, as the ortholog of yeast HRD1, a central component of ER-associated degradation. I have also identified three new LIN-12/Notch target genes, lst-5, lst-6/sqv-7, which are transcriptionally activated by LIN-12/Notch signaling. The three genes share a common 5'upstream region, as lst-6 and sqv-7 are in an operon. I focus on analysis of lst-5, a C2H2 type zinc finger protein, and on the genetic interaction between lin-12 and lst-5. I provide genetic evidence which implies that LST-5 is a LIN-12/Notch target gene which acts to augment lin-12 activity in VPC fate specification and in the AC/VU decision, another LIN-12/Notch mediated decision in the somatic gonad.


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Product Details
  • ISBN-13: 9781243579720
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 476 gr
  • ISBN-10: 1243579722
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 14 mm
  • Width: 189 mm


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Genes That Act in Specification of the Vulval Secondary Fate in Caenorhabditis Elegans
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Genes That Act in Specification of the Vulval Secondary Fate in Caenorhabditis Elegans
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