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The Power of Linkage Analysis of a Quantitative Endophenotype.

The Power of Linkage Analysis of a Quantitative Endophenotype.


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About the Book

In our study, we consider a complex disease with low frequency for which we are studying a disease related trait (endophenotype) instead of the disease itself. We assume that there is a pleiotropic gene that determines both the disease and disease related trait. First we developed software to simulate a quantitative endophenotype and linked markers in sib-pairs ascertained through a single disease affected proband. We simulated data sets of 100 sib-pairs under 210 genetic parameter values for disease allele frequency, disease penetrance, quantitative trait heritability with variable dominance and evaluated the power of the Haseman-Elston test for linkage. We then evaluated these results to estimate the effects of the parameter values and their interactions on power.


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Product Details
  • ISBN-13: 9781243564023
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 245 gr
  • ISBN-10: 1243564024
  • Publisher Date: 03 Sep 2011
  • Binding: Paperback
  • Spine Width: 8 mm
  • Width: 203 mm

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The Power of Linkage Analysis of a Quantitative Endophenotype.
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