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Characterization of Human Cd8+ T Cell Subsets Using Novel Artificial Antigen Presenting Cells

Characterization of Human Cd8+ T Cell Subsets Using Novel Artificial Antigen Presenting Cells


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About the Book

CD8+ T cells play a crucial role in eradicating foreign pathogens and providing immune surveillance to prevent the development of tumors. Antigen presenting cells such as dendritic cells are potent stimulators of T cells. They express an array of molecules, including co-stimulatory ligands and cytokines, responsible for regulating the activation of different T cell subsets. Using lentiviral vector technology, we have developed a novel K562 cell-based artificial antigen presenting cell (aAPC) system, designed to elucidate the precise requirements for activation, growth and expansion of different human CD8+ T cell subsets. Studies utilizing our system demonstrated that 4-1BB ligation restores the growth potential of functional CD8+CD28-T cells, a subset that has previously been associated with replicative senescence and poor proliferative capacity. Other studies revealed that expansion of CD8+ T cells with aAPCs secreting IL-21 resulted in their reduced differentiation, increased cytotoxic potential and enhanced engraftment compared to expansion with IL-15. Additional studies utilizing the aAPCs helped define a role for OX40 in the survival of memory T cells, linking OX40 haploinsufficiency to clinical immunodeficiency. Furthermore, the aAPCs affords a means to understand the complex biology of human T cells, and provides insight for future strategies for cell-based immunotherapies.


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Product Details
  • ISBN-13: 9781243546166
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 340 gr
  • ISBN-10: 1243546166
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 10 mm
  • Width: 189 mm


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Characterization of Human Cd8+ T Cell Subsets Using Novel Artificial Antigen Presenting Cells
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Characterization of Human Cd8+ T Cell Subsets Using Novel Artificial Antigen Presenting Cells
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