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Home > Mathematics and Science Textbooks > Biology, life sciences > The Role of Pkd2 and C21orf59 in Patterning the Left-Right Axis of the Zebrafish Embryo
The Role of Pkd2 and C21orf59 in Patterning the Left-Right Axis of the Zebrafish Embryo

The Role of Pkd2 and C21orf59 in Patterning the Left-Right Axis of the Zebrafish Embryo


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About the Book

An important step in patterning the vertebrate embryo involves the formation of the left-right body axis. Although externally vertebrates appear bilaterally symmetric, an internal asymmetry is manifested through asymmetric placement of visceral and, in zebrafish, diencephalic organs. To gain insight into the genetic events involved in establishing the left-right axis, I have analyzed mutations obtained from a large-scale mutagenesis screen in Zebrafish. My work has focused on the mutants, curly up and kurly, mutations that are marked by "curly tail" phenotypes. Through positional cloning, I find that cup embryos are mutant for polycystic kidney disease 2 (pkd2), a gene that encodes the Ca2+ activated non-specific cation channel, Polycystin-2. Characterization of two alleles of curly up have revealed left-right defects in organ positioning and asymmetric gene expression in the lateral plate mesoderm and dorsal diencephalon, indicating cup functions at an early step in left-right patterning. Although it appears that pkd2 is acting both from the mouse node and zebrafish Kupffer's vesicle (KV) to affect left-right axis determination, the mouse model proposes a role for pkd2 in the activation of asymmetric nodal signaling and the fish places pkd2 in a pathway to restrict asymmetric genes to the left side. Therefore, it is still in question whether the function of pkd2 is conserved in vertebrate symmetry breaking events. Based on morpholino studies, I propose an additional role for maternal pkd2 in general mesendoderm patterning. kurly embryos display similar defects in left-right patterning but are mutant for the novel gene, c21orf59. C21orf59 localizes to the basal body of the cilium in Chlamydomonas, and fish mutant for this gene exhibit a range of defects in cilia motility. Motile cilia are necessary at the node and KV to generate a leftward fluid that is important for the proper initiation of asymmetric gene expression on the left side of the embryo. Since c21orf59 mutant embryos have a mixture of motile and immotile cilia, mutations in this gene should provide new insight into the role of fluid flow in generating the correct left-right axis.


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Product Details
  • ISBN-13: 9781243508249
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 304 gr
  • ISBN-10: 1243508248
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 10 mm
  • Width: 203 mm


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The Role of Pkd2 and C21orf59 in Patterning the Left-Right Axis of the Zebrafish Embryo
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