Buy Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.
close menu
Bookswagon
search
My Account
Home > Technology: general issues > Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.
Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.

Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. The established technique of computed tomography can detect and stage the disease with limited sensitivity and is not suitable for long-term studies due to radiation exposure. In recent years, hyperpolarized 3He (HP 3He) MRI has been studied extensively as a promising tool to assess pulmonary structural and functional parameters. This work focuses on the application of this technique to study pulmonary ventilation and perfusion disorders, with an emphasis on COPD. Two hypotheses are proposed and tested in this thesis. The first hypothesis is that microscopic changes in lung structure induced by COPD cause associated function deteriorations, and HP 3He MRI is capable of quantifying this correlation. To this end, a simultaneous measurement technique is developed for the co-registered measurement of apparent diffusion coefficient (ADC), partial pressure of oxygen (pO2) and oxygen depletion rate (R). In this technique, a mathematical model on signal evolution is proposed and the multiple regression method is applied to extract the values of ADC, pO2 and R from a series of acquired signals. Measurement uncertainty expressions are derived and the key scan parameters are optimized to reduce the noise-induced uncertainty. The technique was first tested on a phantom model, and then on an in-vivo normal pig experiment. A case study was performed on a COPD patient, which showed that, in a region-of-interest ADC was 29% higher while oxygen depletion rate was 61% lower than the corresponding global average values. The second hypothesis is that HP 3He MRI can not only be applied to measure ventilation disorders, but also capable of detecting perfusion defects, such as pulmonary emboli (PE). To test this hypothesis, Gadolinium (Gd) is injected to modify the magnetic susceptibility gradient between lung tissue and air, and this modification is recorded through the phase of the HP 3He MRI signal. A double-echo based method is proposed for the automatic co-registration of lung perfusion and ventilation images. The in-vivo animal experiment showed a significant phase shift followed by the perfusion-induced susceptibility change.


Best Sellers


Product Details
  • ISBN-13: 9781243504425
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 246 mm
  • Weight: 268 gr
  • ISBN-10: 1243504420
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 8 mm
  • Width: 189 mm

Related Categories

Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.
Proquest, Umi Dissertation Publishing -
Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Measurement of Pulmonary Structure and Function Parameters with Hyperpolarized Helium(3) Magnetic Resonance Imaging.

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    Your IP: 216.73.217.72 IN