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Home > Mathematics and Science Textbooks > Biology, life sciences > Mad3p Promotes Non-Exchange Chromosome Segregation Fidelity and Delays Anaphase Onset in Meiosis I of Saccharomyces Cerevisiae.
Mad3p Promotes Non-Exchange Chromosome Segregation Fidelity and Delays Anaphase Onset in Meiosis I of Saccharomyces Cerevisiae.

Mad3p Promotes Non-Exchange Chromosome Segregation Fidelity and Delays Anaphase Onset in Meiosis I of Saccharomyces Cerevisiae.


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About the Book

Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. In humans, chromosomes that fail to experience crossovers (exchanges) are error-prone, more likely than exchange chromosomes to mis-segregate in meiosis. We employed a yeast model to investigate the mechanisms that partition non-exchange chromosomes. These studies demonstrated differential roles for the spindle checkpoint genes MAD1, MAD2 and MAD3. We identified a novel meiotic role for MAD3; though dispensable for the segregation of exchange chromosomes, it is essential for the segregation of non-exchange chromosomes. MAD1 and MAD2 were found to act in a surveillance mechanism that mediates a metaphase delay in response to non-exchange chromosomes, while MAD3 acts as a crucial meiotic timer, mediating a prophase delay in every meiosis. Importantly the function of MAD3 could be complemented byBUB1B, the human homolog of MAD3. Attempts to complement the Mad3p-mediated delay failed to rescue non-exchange chromosome segregation. While we could not identify the mechanism for Mad3p function in meiosis, our results implicate a target other than CDC20 family members. These findings imply a plausible model for the basis of errant meiotic segregation in humans.


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Product Details
  • ISBN-13: 9781243481580
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 349 gr
  • ISBN-10: 1243481587
  • Publisher Date: 02 Sep 2011
  • Binding: Paperback
  • Spine Width: 11 mm
  • Width: 203 mm


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Mad3p Promotes Non-Exchange Chromosome Segregation Fidelity and Delays Anaphase Onset in Meiosis I of Saccharomyces Cerevisiae.
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Mad3p Promotes Non-Exchange Chromosome Segregation Fidelity and Delays Anaphase Onset in Meiosis I of Saccharomyces Cerevisiae.
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