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Home > Art, Film & Photography > Pde-5-Hemmer: Sildenafil, Vardenafil, Tadalafil
Pde-5-Hemmer: Sildenafil, Vardenafil, Tadalafil

Pde-5-Hemmer: Sildenafil, Vardenafil, Tadalafil


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About the Book

Aus Wikipedia. Nicht dargestellt. Auszug: Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the US Food and Drug Administration on March 27, 1998, becoming the first oral treatment approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. It soon became a great success: annual sales of Viagra in the period 1999-2001 exceeded $1 billion. The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim that Pfizer disputes. Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience. Even though sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on U.S. TV (famously being endorsed by forme...http://booksllc.net/?l=de


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Product Details
  • ISBN-13: 9781159244149
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 32
  • Spine Width: 2 mm
  • Weight: 59 gr
  • ISBN-10: 1159244146
  • Publisher Date: 22 Jul 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Sildenafil, Vardenafil, Tadalafil
  • Width: 229 mm


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