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Home > Art, Film & Photography > Gnrh Antagonists: Degarelix, Abarelix, Cetrorelix, Ganirelix
Gnrh Antagonists: Degarelix, Abarelix, Cetrorelix, Ganirelix

Gnrh Antagonists: Degarelix, Abarelix, Cetrorelix, Ganirelix


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About the Book

Chapters: Degarelix, Abarelix, Cetrorelix, Ganirelix. Source: Wikipedia. Pages: 18. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Degarelix - On 24 December 2008, the Food and Drug Administration (FDA) approved degarelix for the treatment of patients with advanced prostate cancer in the USA. It was subsequently approved by the European Commission at the recommendation of the European Medicines Agency (EMEA) on February 17 2009 for use in adult male patients with advanced, hormone-dependent prostate cancer. Ferring Pharmaceuticals markets the drug under the name Firmagon. GnRH antagonists (receptor blockers) such as degarelix are a new type of hormonal therapy for prostate cancer. These agents are synthetic peptide derivatives of the natural GnRH decapeptide a hormone that is made by neurons in the hypothalamus. GnRH antagonists compete with natural GnRH for binding to GnRH receptors in the pituitary gland. This reversible blinding blocks the release of LH and FSH from the pituitary. The reduction in LH subsequently leads to a rapid and sustained suppression of testosterone release from the testes and subsequently reduces the size and growth of the prostate cancer. This in turn results in a reduction in prostate-specific antigen (PSA) levels in the patient's blood. Measuring PSA levels is a way to monitor how patients with prostate cancer are responding to treatment. Unlike the GnRH agonists, which cause an initial stimulation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to a surge in testosterone levels, and under certain circumstances, a flare-up of the tumour, GnRH antagonists do not cause a surge in testosterone or clinical flare. Clinical flare is a phenomenon that occurs in patients with advanced disease, which can precipitate a range of clinical symptoms such as bo...More: http: //booksllc.net/?id=20947551


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Product Details
  • ISBN-13: 9781158391561
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Degarelix, Abarelix, Cetrorelix, Ganirelix
  • Width: 229 mm
  • ISBN-10: 1158391560
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 1 mm
  • Weight: 45 gr


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