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Home > Art, Film & Photography > EC 3.1.21: Deoxyribonuclease I, R.Ecorii, Ecorv, Deoxyribonuclease II
EC 3.1.21: Deoxyribonuclease I, R.Ecorii, Ecorv, Deoxyribonuclease II

EC 3.1.21: Deoxyribonuclease I, R.Ecorii, Ecorv, Deoxyribonuclease II


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About the Book

Chapters: Deoxyribonuclease I, R.ecorii, Ecorv, Deoxyribonuclease Ii. Source: Wikipedia. Pages: 26. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. It has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information. This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. ...More: http: //booksllc.net/?id=550705


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Product Details
  • ISBN-13: 9781158374809
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Deoxyribonuclease I, R.Ecorii, Ecorv, Deoxyribonuclease II
  • Width: 229 mm
  • ISBN-10: 1158374801
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 54 gr


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