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Home > Art, Film & Photography > Crf-1 Antagonists: Antalarmin, Pexacerfont, Cp-154,526, Corticotropin Releasing Hormone Antagonist
Crf-1 Antagonists: Antalarmin, Pexacerfont, Cp-154,526, Corticotropin Releasing Hormone Antagonist

Crf-1 Antagonists: Antalarmin, Pexacerfont, Cp-154,526, Corticotropin Releasing Hormone Antagonist


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About the Book

Chapters: Antalarmin, Pexacerfont, Cp-154,526, Corticotropin Releasing Hormone Antagonist. Source: Wikipedia. Pages: 17. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Antalarmin is a drug that acts as a CRF-1 antagonist. Corticotropin-releasing factor (CRF), also known as Corticotropin-releasing hormone, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. This, then, triggers the release of corticotropin (ACTH), another hormone involved in the physiological response to stress. Chronic release of CRF and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, stomach ulcers, anxiety, diabetes mellitus, osteoporosis, depression, and development of high blood pressure and consequent cardiovascular problems. Antalarmin is a non-peptide drug that blocks the CRF-1 receptor, and, as a consequence, reduces the release of ACTH in response to chronic stress. This has been demonstrated in animals to reduce the behavioural responses to stressful situations, and it is proposed that antalarmin itself, or more likely newer CRF antagonist drugs still under development, could be useful for reducing the adverse health consequences of chronic stress in humans, as well as having possible uses in the treatment of conditions such as anxiety, depression, and drug addiction. Results so far have had limited success, with various CRF antagonists being tested, which showed some antidepressant effects, but failed to produce an effect comparable with conventional antidepressant drugs. However more positive results were seen when antalarmin was combined with an SSRI antidepressant, suggesting a potential for synergistic effect. Encouraging results ...More: http: //booksllc.net/?id=1580318


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Product Details
  • ISBN-13: 9781158350735
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 18
  • Spine Width: 1 mm
  • Weight: 41 gr
  • ISBN-10: 1158350732
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Antalarmin, Pexacerfont, Cp-154,526, Corticotropin Releasing Hormone Antagonist
  • Width: 229 mm


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