About the Book
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 27. Chapters: Fentanyl, Atorvastatin, Leflunomide, Bicalutamide, Platensimycin, Remifentanil, Ertapenem, Dasatinib, Acebutolol, Flutamide, Vorinostat, Ropivacaine, Alpha-Methylfentanyl, SNAP-7941, Fenretinide, Teriflunomide, 3-Methylfentanyl, Carfentanil, Ivacaftor, Mepivacaine, Levobupivacaine, AM404, Leteprinim, Trefentanil, Alfentanil, Sufentanil, Ohmefentanyl, SNAP-94847, Phenaridine, Betahydroxythiofentanyl, Prilocaine, 3-Methylthiofentanyl, Parafluorofentanyl, Betahydroxyfentanyl, Alphamethylthiofentanyl, S-23, Suplatast tosilate, 4-Phenylfentanyl, 3-Allylfentanyl, Phenampromide, Lorcainide, Dalcetrapib, Betamethylfentanyl, Adipiodone, Ancarolol, Etidocaine, Propanil, Iobitridol, Iodoxamic acid, Cinanserin, Iotrolan, WAY-317,538, Iocarmic acid, VDM-11, Tyropanoic acid, Succinylsulfathiazole. Excerpt: Fentanyl (also known as fentanil, brand names Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Onsolis, Instanyl, Abstral, and others) is a potent synthetic narcotic analgesic with a rapid onset and short duration of action. It is a strong agonist at the -opioid receptors. Historically it has been used to treat chronic breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine. Fentanyl is approximately 100 times more potent than morphine, with 100 micrograms of fentanyl approximately equivalent to 10 mg of morphine and 75 mg of pethidine (meperidine) in analgesic activity. It has an LD50 of 3.1 milligrams per kilogram in rats, and an LD50 of 0.03 milligrams per kilogram in monkeys. Fentanyl was first synthesized by Dr. Paul Janssen in 1960 following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally-related drug pethidine for opioid activity. The widespread use of fentanyl ...
