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Home > Art, Film & Photography > Pyrazolones: Metamizole, Phenylbutazone, Phenazone, Aminophenazone, Ampyrone, Suxibuzone, Sulfamazone, Nifenazone, Pyrazolone, Propyphenazone
Pyrazolones: Metamizole, Phenylbutazone, Phenazone, Aminophenazone, Ampyrone, Suxibuzone, Sulfamazone, Nifenazone, Pyrazolone, Propyphenazone

Pyrazolones: Metamizole, Phenylbutazone, Phenazone, Aminophenazone, Ampyrone, Suxibuzone, Sulfamazone, Nifenazone, Pyrazolone, Propyphenazone


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About the Book

Chapters: Metamizole, Phenylbutazone, Phenazone, Aminophenazone, Ampyrone, Suxibuzone, Sulfamazone, Nifenazone, Pyrazolone, Propyphenazone. Source: Wikipedia. Pages: 37. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Metamizole sodium is a non-steroidal anti-inflammatory drug (NSAID), commonly used in many countries as a powerful analgesic and antipyretic. It is better known under the names Dipyrone, Analgin, Novalgin, Algocalmin, and Melubrin. Metamizole was first synthesized by the German company Hoechst AG (now part of Sanofi-Aventis) in 1920, and its mass production started in 1922. It remained freely available worldwide until the 1970s, when it was discovered that the drug carries a small risk of causing agranulocytosis - a potentially fatal condition. Controversy remains regarding the level of risk. Several national medical authorities have banned metamizole either totally or have restricted it to be available only on prescription, while others have maintained its availability over the counter. According to comments by Dr. Anthony Wong of the University of Sao Paulo, Brazil in a WHO newsletter, recent studies estimate that the incidence rate of metamizole-induced agranulocytosis is between 0.2 and 2 cases per million person days of use, with approximately 7% of all cases fatal (provided that all patients have access to urgent medical care). In other words, one should expect 50 to 500 deaths annually due to metamizole in a country of 300 million, assuming that every citizen takes the drug once a month. This is not a very high rate compared to other drugs - for example, the prescription drug clozapine is known to be at least 50 times more likely to trigger agranulocytosis. However, at the time the risk was assumed to be much greater and, as such, excessive for an over-the-counter ana...More: http: //booksllc.net/?id=298888


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Product Details
  • ISBN-13: 9781157441458
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Metamizole, Phenylbutazone, Phenazone, Aminophenazone, Ampyrone, Suxibuzone, Sulfamazone, Nifenazone, Pyrazolone, Propyphenazone
  • Width: 229 mm
  • ISBN-10: 1157441459
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 68 gr


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