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Home > Art, Film & Photography > Hydroxamic Acids: Hydroxamic Acid, Deferoxamine, Adrafinil, Vorinostat, Trichostatin A, Tepoxalin, Salicylhydroxamic Acid, Crl-40,941
Hydroxamic Acids: Hydroxamic Acid, Deferoxamine, Adrafinil, Vorinostat, Trichostatin A, Tepoxalin, Salicylhydroxamic Acid, Crl-40,941

Hydroxamic Acids: Hydroxamic Acid, Deferoxamine, Adrafinil, Vorinostat, Trichostatin A, Tepoxalin, Salicylhydroxamic Acid, Crl-40,941


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Chapters: Hydroxamic Acid, Deferoxamine, Adrafinil, Vorinostat, Trichostatin A, Tepoxalin, Salicylhydroxamic Acid, Crl-40,941, Bufexamac, Acetohydroxamic Acid, Oxametacin, Ibuproxam. Source: Wikipedia. Pages: 38. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: A hydroxamic acid is a class of chemical compounds sharing the same functional group in which an hydroxylamine is inserted into a carboxylic acid. Its general structure is R-CO-NH-OH, with an R as an organic residue, a CO as a carbonyl group, and a hydroxylamine as NH2-OH. They are used as metal chelators. Hydroxamic acids can be synthesized from aldehydes via the Angeli-Rimini reaction. A well-known hydroxamic acid reaction is the Lossen rearrangement. Hydroxamates are essential growth factors, or vitamins, for some microbes. They function as iron-binding compounds (siderophores) that solubilise iron and transport it into the cell. Iron is a key component of cytochromes and iron-sulphur proteins (involved in electron transport) and is thus important in cellular respiration. In an environment, absent from oxygen (anoxic); iron will be present in the ferrous +2 oxidation state (Fe), which is water-soluble. Under oxic conditions; iron will be in the ferric +3 oxidation state (Fe), in insoluble mineral form. The powerful chelating properties of hydroxamic acid and its derivatives is exploited by bacteria to obtain ferric iron. Once the iron-hydroxamate complex has entered the cell, the iron is liberated and the hydroxamic acid can be excreted and reused for iron transport. Some hydroxamic acids (eg. SAHA (Vorinostat), PXD101 (Belinostat), and LAQ824/LBH589, and Trichostatin A) are HDAC inhibitors with anti-cancer properties. A hydroxamic acid is a class of chemical compounds sharing the same functional group in which an hydroxylamine i...More: http: //booksllc.net/?id=695044


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Product Details
  • ISBN-13: 9781157404910
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Hydroxamic Acid, Deferoxamine, Adrafinil, Vorinostat, Trichostatin A, Tepoxalin, Salicylhydroxamic Acid, Crl-40,941
  • Width: 229 mm
  • ISBN-10: 115740491X
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 3 mm
  • Weight: 73 gr


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