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Home > Art, Film & Photography > EC 5.99.1 EC 5.99.1: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV
EC 5.99.1 EC 5.99.1: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV

EC 5.99.1 EC 5.99.1: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV


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About the Book

Chapters: Type Ii Topoisomerase, Type I Topoisomerase, Dna Gyrase, Topoisomerase Iv. Source: Wikipedia. Pages: 30. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Type II topoisomerases cut both strands of the DNA helix simultaneously in order to unwind it. Once cut, the ends of the DNA are separated, and a second DNA duplex is passed through the break. Following passage, the cut DNA is religated. This reaction allows type II topoisomerases to increase or decrease the linking number of a DNA loop by 2 units, and promotes chromosome disentanglement. Reactions involving the increase in supercoiling require two molecules of ATP. Janet Lindsley has done much work to examine how the hydrolysis of ATP translate to topo function. For example, DNA gyrase, a type II topoisomerase observed in E. coli and most other prokaryotes, introduces negative supercoils and decreases the linking number by 2. Gyrase also is able to remove knots from the bacterial chromosome. Along with gyrase, most prokaryotes also contain a second type IIA topoisomerase, termed topo IV. Gyrase and topo IV differ by their C-terminal domains, which is believed to dictate substrate specificity and functionality for these two enzymes. Footprinting indicates that gyrase, which forms a 140-base-pair footprint, wraps DNA allowing it to introduce negative supercoils, while topo IV, which forms a 28-base-pair footprint, does not wrap DNA. Eukaryotic type II topoisomerase cannot introduce supercoils; it can only relax them. This is thought to be unnecessary because the binding of DNA by histones increases potential superhelicity. The role of type IIB topoisomerases is less understood. Unlike type II topoisomerases, it cannot simplify DNA topology (see below) but it shares several structural features with type IIA topoisomerases. Type II...More: http: //booksllc.net/?id=899649



Product Details
  • ISBN-13: 9781157064039
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV
  • Width: 229 mm
  • ISBN-10: 1157064035
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 59 gr


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EC 5.99.1 EC 5.99.1: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV
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EC 5.99.1 EC 5.99.1: Type II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Toptype II Topoisomerase, Type I Topoisomerase, DNA Gyrase, Topoisomerase IV Oisomerase IV

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