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Home > Art, Film & Photography > Ligands: Sonic Hedgehog, Flt3lg, Ligand, Tppts, 2,2'-Bis(2-Indenyl) Biphenyl, Spiroxatrine
Ligands: Sonic Hedgehog, Flt3lg, Ligand, Tppts, 2,2'-Bis(2-Indenyl) Biphenyl, Spiroxatrine

Ligands: Sonic Hedgehog, Flt3lg, Ligand, Tppts, 2,2'-Bis(2-Indenyl) Biphenyl, Spiroxatrine


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About the Book

Chapters: Sonic Hedgehog, Flt3lg, Ligand, Tppts, 2,2'-Bis(2-Indenyl) Biphenyl, Spiroxatrine. Source: Wikipedia. Pages: 31. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Sonic hedgehog homolog (SHH) is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag modela molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in development of some cancers. The hedgehog gene (hh) was first identified in the classic Heidelberg screens of Eric Wieschaus and Christiane Nusslein-Volhard, as published in 1978. These screens, which led to their winning the Nobel Prize in 1995 along with developmental geneticist Edward B. Lewis, identified genes that control the segmentation pattern of Drosophila melanogaster (fruit fly) embryos. The hh loss of function mutant phenotype causes the embryos to be covered with denticles (small pointy projections), resembling a hedgehog. Investigations aimed at finding a hedgehog equivalent in mammals revealed three homologous genes. The first two discovered, desert hedgehog and Indian hedgehog, were named for species of hedgehogs, while sonic hedgehog was named after Sega's video game character Sonic the Hedgehog. In zebrafish, the orthologues of the three mammalian hh genes are: shh a, s...More: http: //booksllc.net/?id=35369


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Product Details
  • ISBN-13: 9781156953433
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 32
  • Spine Width: 2 mm
  • Weight: 59 gr
  • ISBN-10: 115695343X
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Sonic Hedgehog, Flt3lg, Ligand, Tppts, 2,2'-Bis(2-Indenyl) Biphenyl, Spiroxatrine
  • Width: 229 mm


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