About the Book
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF- B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1, FADD, Bcl-2-associated death promoter, IKK2, Fas receptor, Fas ligand, Bcl-2-associated X protein, Autophagy, APAF1, Neurotrophin, CARD domain, Poly ADP ribose polymerase, BH3 interacting domain death agonist, Caspase, History and highlights in apoptosis research, Noxa, TrkC receptor, Perforin, PAC-1, Apoptosis-inducing factor, The Proteolysis Map, Paracaspase, 14-3-3 protein, Mitochondrial apoptosis-induced channel, Anoikis, Bleb, TUNEL assay, Autolysis, Granzyme, Necrobiology, Metacaspase, DNA laddering, Phenoptosis, P53 upregulated modulator of apoptosis, Pyknosis, Karyolysis, Autophagy database, Autoschizis, Pyroptosis, Suicide gene, Bcl-2 homologous antagonist killer, Karyorrhexis, Mitotic catastrophe, Death-inducing signaling complex, UVB-induced apoptosis. Excerpt: p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," the "guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation. The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of proline residues in the protein, which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. p53 is...
