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Home > Art, Film & Photography > EC 3.6.5: Rho Family of Gtpases
EC 3.6.5: Rho Family of Gtpases

EC 3.6.5: Rho Family of Gtpases


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About the Book

Chapters: Rho Family of Gtpases. Source: Wikipedia. Pages: 39. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: The Rho family of GTPases is a family of small ( 21 kDa) signaling G protein (more specific, a GTPase), and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants. Three members of the family have been studied a great deal: Cdc42, Rac1, and RhoA. Rho proteins have been described as "molecular switches" and play a role in cell proliferation, apoptosis, gene expression, and multiple other common cellular functions. Identification of the Rho family of GTPases began in the mid 1980s. The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. Rac1 and Rac2 were next identified in 1989 followed by Cdc42 in 1990 . Eight additional mammalian Rho members were identified from biological screenings until the late 1990s, a turning point in biology where availability of complete genome sequences allowed full identification of gene families. In mammals, the Rho family is thus made of 20 members distributed into eight subfamilies: Rho, Rnd, RhoD/F, RhoH, Rac, Cdc42, RhoU/V and RhoBTB . As early as 1990, Paterson et al. began injecting active rho protein into Swiss 3T3 cells.. In the 2006 review article released by Bement et al., the spatial zones of rho activation were explained. As early as the mid-1990s, these processes and the effects of the rho proteins were observed in fibroblasts. Dr. Alan Hall, one of the front-runners in rho protein research, compiled evidence in his 1998 review, which showed that it is not only fibroblasts that formed processes based on rho activa...More: http: //booksllc.net/?id=11158878


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Product Details
  • ISBN-13: 9781156446249
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 40
  • Spine Width: 3 mm
  • Weight: 73 gr
  • ISBN-10: 1156446244
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Rho Family of Gtpases
  • Width: 229 mm


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