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Home > Art, Film & Photography > Nk1 Receptor Antagonists: Nk1 Receptor Antagonist, Aprepitant, L-733,060, Ezlopitant, Fosaprepitant, Casopitant, Vestipitant
Nk1 Receptor Antagonists: Nk1 Receptor Antagonist, Aprepitant, L-733,060, Ezlopitant, Fosaprepitant, Casopitant, Vestipitant

Nk1 Receptor Antagonists: Nk1 Receptor Antagonist, Aprepitant, L-733,060, Ezlopitant, Fosaprepitant, Casopitant, Vestipitant


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About the Book

Chapters: Nk1 Receptor Antagonist, Aprepitant, L-733,060, Ezlopitant, Fosaprepitant, Casopitant, Vestipitant. Source: Wikipedia. Pages: 37. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Neurokinin 1 (NK1) antagonists are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy. An example of a drug in this class is aprepitant. Chemotherapy-induced emesis appears to consist of acute and delayed phases. So far the acute phase emesis responds to 5-HT3 antagonists while the delayed phase remains difficult to control. The discovery and development of NK1 receptor antagonists have elicited antiemetic effect in both acute and especially in delayed phases of emesis. The first registered clinical use of NK1 receptor antagonists was the treatment of emesis, associated with cancer chemotherapy. In 1931, von Euler and Gaddum discovered substance P (SP) in horse brain and intestine. The substance showed strong vasodilatory effects and contractile activity on the rabbit gut. A great effort was put in to purifying this substance from diverse mammalian tissue, but without success for over 30 years. Nonmammalian peptides, that elicited the same vasodilatory and contractile effects as SP, were discovered by Erspamer in the early 1960s. These peptides had a common iterminal sequence and were grouped together as tachykinins. In 1971 Chang managed to purify SP from horse intestine and identify its amino acid sequence and as a result SP was classified as a mammalian tachykinin. In the 1970s it became clear that SP was a neuropeptide that was common in the central and peripheral nervous system. In the mid 198...More: http://booksllc.net/?id=8596694


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Product Details
  • ISBN-13: 9781156262009
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Nk1 Receptor Antagonist, Aprepitant, L-733,060, Ezlopitant, Fosaprepitant, Casopitant, Vestipitant
  • Width: 229 mm
  • ISBN-10: 1156262003
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 68 gr


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